506028 Cell Proliferation Inducer, WS3 - Calbiochem

506028
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₈H₃₀F₃N₇O₃•HCl

Pricing & Availability

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5.06028.0001
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, diarylurea analog that can reversibly induce cell proliferation of primary retinal pigment epithelial (RPE) cells from rodents and from fetal and adult human donors (~ 25 nM). Its action suggested to be mediated through Erb3 binding protein 1 (Ebp1). Non-proliferating RPE cells at passage 6 appear to respond well to WS3 treatment, whereas actively proliferating cells in passage 1 to 4 do not exhibit any increase in proliferation. These cells can differentiate into functional monolayer following WS3 withdrawal. However, WS3-expanded adult human RPE cells differentiate less effectively when compared to stem cell-derived RPE cells. The expanded RPE cells are shown to preserve vision when transplanted into rodent models of retinal degeneration. Also shown to induce proliferation of mouse R7T1 β cells (EC50 = 74 nM). Not reported to induce any genetic changes or tumorigenic events.
      Catalogue Number506028
      Brand Family Calbiochem®
      SynonymsN-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide Hydrochloride
      References
      ReferencesSwoboda, J.G., et al, 2013. ACS Chem. Biol. 8, 1407.
      Shen, W., et al, 2013. J. Am. Chem. Soc. 135, 1669.
      Product Information
      FormTan solid
      FormulationSupplied as a hydrochloride salt.
      Hill FormulaC₂₈H₃₀F₃N₇O₃•HCl
      Chemical formulaC₂₈H₃₀F₃N₇O₃•HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cell Proliferation Inducer, WS3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Swoboda, J.G., et al, 2013. ACS Chem. Biol. 8, 1407.
      Shen, W., et al, 2013. J. Am. Chem. Soc. 135, 1669.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-December-2013 JSW
      SynonymsN-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide Hydrochloride
      DescriptionA cell-permeable, diarylurea analog that can reversibly induce cell proliferation of primary retinal pigment epithelial (RPE) cells from rodents and from fetal and adult human donors (~ 25 nM). Its action suggested to be mediated through Erb3 binding protein 1 (Ebp1). Non-proliferating RPE cells at passage 6 appear to respond well to WS3 treatment, whereas actively proliferating cells in passage 1 to 4 do not exhibit any increase in proliferation. These cells can differentiate into functional monolayer following WS3 withdrawal. However, WS3-expanded adult human RPE cells differentiate less effectively when compared to stem cell-derived RPE cells. The expanded RPE cells are shown to preserve vision when transplanted into rodent models of retinal degeneration. Also shown to induce proliferation of mouse R7T1 β cells (EC50 = 74 nM). Not reported to induce any genetic changes or tumorigenic events.
      FormTan solid
      FormulationSupplied as a hydrochloride salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₈H₃₀F₃N₇O₃•HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml) or H₂O (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSwoboda, J.G., et al, 2013. ACS Chem. Biol. 8, 1407.
      Shen, W., et al, 2013. J. Am. Chem. Soc. 135, 1669.