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238803 Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₀H₂₈N₆O₃ 199986-75-9

Pricing & Availability

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238803-1MG
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      238803-5MG
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          Description
          OverviewA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
          Catalogue Number238803
          Brand Family Calbiochem®
          Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
          References
          ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
          Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
          Product Information
          CAS number199986-75-9
          ATP CompetitiveY
          DeclarationSold under license of U.S. Patents 6,617,331 and 6,803,371.
          FormWhite to off-white solid
          Hill FormulaC₂₀H₂₈N₆O₃
          Chemical formulaC₂₀H₂₈N₆O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCdk2/A, Cdk2/E
          Primary Target IC<sub>50</sub>0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          238803

          References

          Reference overview
          Bhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
          Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-October-2020 JSW
          Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
          DescriptionA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number199986-75-9
          Chemical formulaC₂₀H₂₈N₆O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
          Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.