217720 Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₉H₇N₅ 40254-90-8

Pricing & Availability

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217720-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC50 = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3β with (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 > 10 µM).
      Catalogue Number217720
      Brand Family Calbiochem®
      Synonyms3-Amino-1H-pyrazolo[3,4-b]quinoxaline
      References
      ReferencesOrtega, M.A., et al. 2002. Bioorg. Med. Chem. 10, 2177.
      Product Information
      CAS number40254-90-8
      ATP CompetitiveN
      FormRed solid
      Hill FormulaC₉H₇N₅
      Chemical formulaC₉H₇N₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk1/cyclin B, Cdk5/p25
      Primary Target IC<sub>50</sub>0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      217720

      References

      Reference overview
      Ortega, M.A., et al. 2002. Bioorg. Med. Chem. 10, 2177.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2007 RFH
      Synonyms3-Amino-1H-pyrazolo[3,4-b]quinoxaline
      DescriptionA selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdk1/Cdk5) (IC50 = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25). Also shown to inhibit glycogen synthase kinase-3β (GSK-3β) (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 > 10 µM).
      FormRed solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number40254-90-8
      Chemical formulaC₉H₇N₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesOrtega, M.A., et al. 2002. Bioorg. Med. Chem. 10, 2177.