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208743 Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem

The Calpain Inhibitor XI, also referenced under CAS 145731-49-3, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-L-Abu-CONH(CH₂)₃-morpholine

Primary Target: calpain 1, calpain 2
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208743
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
145731-49-3C₂₆H₄₀N₄O₆

Pricing & Availability

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      208743-5MG
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          Description
          OverviewA cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2 (Ki = 140 nM and 41 nM, respectively). Weakly inhibits cathepsin B (Ki = 6.9 µM). Reported to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
          Catalogue Number208743
          Brand Family Calbiochem®
          SynonymsZ-L-Abu-CONH(CH₂)₃-morpholine
          References
          ReferencesBlomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
          DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
          Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
          Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
          Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
          James, T., et al. 1998. J. Neurosci. Res. 51, 218.
          Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
          Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
          Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
          Bartus, R.T., et al. 1994. Stroke 25, 2265.
          Product Information
          CAS number145731-49-3
          ATP CompetitiveN
          FormWhite to off-white solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₂₆H₄₀N₄O₆
          Chemical formulaC₂₆H₄₀N₄O₆
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetcalpain 1, calpain 2
          Primary Target K<sub>i</sub>140 nM and 41 nM, against calpain-1 and -2, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Identification Number
          Catalog Number GTIN
          208743-1MG4055977202793
          208743-5MG4055977202809

          Documentation

          Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          208743

          References

          Reference overview
          Blomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
          DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
          Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
          Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
          Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
          James, T., et al. 1998. J. Neurosci. Res. 51, 218.
          Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
          Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
          Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
          Bartus, R.T., et al. 1994. Stroke 25, 2265.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-May-2011 JSW
          SynonymsZ-L-Abu-CONH(CH₂)₃-morpholine
          DescriptionA cell-permeable dipeptidyl a-ketoamide that acts as a potent, highly selective, reversible, active site inhibitor of calpain-1 (Ki = 140 nM) and calpain-2 (Ki = 41 nM). Weakly inhibits cathepsin B (Ki = 6.9 µM). Shown to inhibit calpain-m-mediated degradation of neurofilament protein (NFP) (IC50 = 600 nM). Also shown to exhibit neuroprotective effects in the central nervous system following focal ischemia. Reported to protect against reovirus-induced myocarditis in mice.
          FormWhite to off-white solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number145731-49-3
          Chemical formulaC₂₆H₄₀N₄O₆
          Peptide SequenceZ-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBlomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
          DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
          Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
          Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
          Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
          James, T., et al. 1998. J. Neurosci. Res. 51, 218.
          Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
          Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
          Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
          Bartus, R.T., et al. 1994. Stroke 25, 2265.