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504522 CNS-1102 - CAS 137159-92-3 - Calbiochem

CNS-1102 - CAS 137159-92-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NMDA Antagonist V, N-(3-Ethylphenyl)-N-methyl-N’-1-naphthalenylguanidine hydrochloride, Cerestat, Aptiganel hydrochloride

Primary Target: NMDA receptors
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504522
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
137159-92-3C₂₀H₂₁N₃ • HCl

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      Description
      OverviewA non-competitive, subunit non-selective, potent antagonist for NMDA receptors (IC50 = 0.13, 0.068, 0.087, and 0.14 µM for NR2A - D, respectively). Widely used as neuroprotective agent after acute traumatic brain injury and stroke in animal researches.
      Catalogue Number504522
      Brand Family Calbiochem®
      SynonymsNMDA Antagonist V, N-(3-Ethylphenyl)-N-methyl-N’-1-naphthalenylguanidine hydrochloride, Cerestat, Aptiganel hydrochloride
      References
      ReferencesReddy, N., et al. 1994. J. Medicinal Chemistry. 37, 260.
      Muir, K., et al. 1994. British J. Clinical Pharmacol. 38, 33.
      Schäbitz, W., et al. 2000. Stroke. 31, 1709.
      Hoyte, L., et al. 2004. Current Molecular Medicine. 4, 131.
      Turner, R., et al. 2013. J. of Neurosurgery. 1, 14.
      Product Information
      CAS number137159-92-3
      FormWhite solid
      FormulationSupplied as a hydrochloride salt.
      Hill FormulaC₂₀H₂₁N₃ • HCl
      Chemical formulaC₂₀H₂₁N₃ • HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Primary Target IC<sub>50</sub>0.13, 0.068, 0.087, and 0.14 µM for NR2A –D, respectively.
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      CNS-1102 - CAS 137159-92-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Reddy, N., et al. 1994. J. Medicinal Chemistry. 37, 260.
      Muir, K., et al. 1994. British J. Clinical Pharmacol. 38, 33.
      Schäbitz, W., et al. 2000. Stroke. 31, 1709.
      Hoyte, L., et al. 2004. Current Molecular Medicine. 4, 131.
      Turner, R., et al. 2013. J. of Neurosurgery. 1, 14.

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      SynonymsNMDA Antagonist V, N-(3-Ethylphenyl)-N-methyl-N’-1-naphthalenylguanidine hydrochloride, Cerestat, Aptiganel hydrochloride
      DescriptionA non-competitive, subunit non-selective, potent antagonist for NMDA receptors (IC50 = 0.13, 0.068, 0.087, and 0.14 µM for NR2A - D, respectively). Widely used as neuroprotective agent after acute traumatic brain injury and stroke in animal researches.
      FormWhite solid
      FormulationSupplied as a hydrochloride salt.
      CAS number137159-92-3
      Chemical formulaC₂₀H₂₁N₃ • HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (17 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesReddy, N., et al. 1994. J. Medicinal Chemistry. 37, 260.
      Muir, K., et al. 1994. British J. Clinical Pharmacol. 38, 33.
      Schäbitz, W., et al. 2000. Stroke. 31, 1709.
      Hoyte, L., et al. 2004. Current Molecular Medicine. 4, 131.
      Turner, R., et al. 2013. J. of Neurosurgery. 1, 14.