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504519 CIQ - CAS 486427-17-2 - Calbiochem

504519
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Key Specifications Table

Empirical FormulaCAS #
C₂₆H₂₆ClNO₅ 486427-17-2

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      Glass bottle 5 mg
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      Description
      OverviewA positive allosteric modulator selective for NR2C/D containing NMDA receptors (EC50 = 2.7 and 2.8 µM for NR2C and NR2D, respectively). Increases channel opening frequency of recombinant NR2C/D containing NMDA receptors by two-fold without altering mean open time or EC50 values for glutamate or glycine bindings. No effect on NR2A or NR2B subtypes.
      Catalogue Number504519
      Brand Family Calbiochem®
      Synonyms(3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
      References
      ReferencesMullasseril, P., et al. 2010. Nat. Commun. 1, 1038.
      Ogden, K., et al. 2013. Mol. Pharmacol. 83, 1045.
      Product Information
      CAS number486427-17-2
      FormWhite powder
      Hill FormulaC₂₆H₂₆ClNO₅
      Chemical formulaC₂₆H₂₆ClNO₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      CIQ - CAS 486427-17-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Mullasseril, P., et al. 2010. Nat. Commun. 1, 1038.
      Ogden, K., et al. 2013. Mol. Pharmacol. 83, 1045.

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      Synonyms(3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
      DescriptionA positive allosteric modulator selective for NR2C/D containing NMDA receptors (EC50 = 2.7 and 2.8 µM for NR2C and NR2D, respectively). Increases channel opening frequency of recombinant NR2C/D containing NMDA receptors by two-fold without altering mean open time or EC50 values for glutamate or glycine bindings. No effect on NR2A or NR2B subtypes.
      FormWhite powder
      CAS number486427-17-2
      Chemical formulaC₂₆H₂₆ClNO₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml). Slight warming is required for complete solubilization.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMullasseril, P., et al. 2010. Nat. Commun. 1, 1038.
      Ogden, K., et al. 2013. Mol. Pharmacol. 83, 1045.