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SCT077 BioTracker TiNIR HMOX2 Live Cell Dye

Near-Infrared probe for detection and isolation of HMOX2 expressing tumor initiating cells.

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SCT077
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT077
      DescriptionBioTracker TiNIR HMOX2 Live Cell Dye
      OverviewIncreasing evidence suggests that a small population of tumor initiating cells (TIC) or cancer stem cells (CSC) are responsible for tumorigenesis and resistance to conventional anti-cancer therapies. Heme oxygenase 2 (HMOX2) has recently been identified as a novel biomarker for tumor initiating cells (1).

      BioTracker TiNIR HMOX2 Live Cell Dye is a near-infrared (NIR) fluorescent probe for the detection and isolation of HMOX2 expressing tumor initiating cells. At low concentrations or a single injection of high concentration, TiNIR (tumor initiating cell probe with near infrared) is useful for the isolation of TIC in vitro and in vivo visualization in tumor model animals, respectively. At high concentrations or repeated treatments, TiNIR has been shown to inhibit the function of HMOX2 and induce tumor cell death by accumulating ROS in cancer cells (1).

      Spectral Properties
      Absorbance: 805 nm
      Emission: 825 nm

      Reference:
      1. Kim, J. J., Lee, Y. A., Su, D., Lee, J., Park, S. J., Kim, B., ... & Chang, Y. T. (2019). A near-infrared probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society, 141(37), 14673-14686.
      Alternate Names
      • Live Cell Imaging Probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized. Green solid.
      Applications
      ApplicationNear-Infrared probe for detection and isolation of HMOX2 expressing tumor initiating cells.
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging
      Biological Information
      Molecular Weight797.82
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      SCT077 04061841827931