504345 BX471 - CAS 217645-70-0 - Calbiochem

BX471 - CAS 217645-70-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752

Primary Target: CCR1
504345
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₄ClFN₄O₃ 217645-70-0

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.04345.0001
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          		 Glass bottle 5 mg
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          Description
          OverviewAn orally active, selective antagonist for chemokine receptor 1 (CCR-1) (Ki = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.
          Catalogue Number504345
          Brand Family Calbiochem®
          SynonymsN-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
          References
          ReferencesShahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
          Reuss, R., et al. 2010. Mult Scler. 16, 366.
          Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
          Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
          Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.
          Product Information
          CAS number217645-70-0
          FormWhite to beige powder
          Hill FormulaC₂₁H₂₄ClFN₄O₃
          Chemical formulaC₂₁H₂₄ClFN₄O₃
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCCR1
          Primary Target K<sub>i</sub>1-5 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          BX471 - CAS 217645-70-0 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Shahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
          Reuss, R., et al. 2010. Mult Scler. 16, 366.
          Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
          Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
          Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2019 JSW
          SynonymsN-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
          DescriptionAn orally active, selective antagonist for chemokine receptor 1 (CCR-1) (Ki = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.
          FormWhite to beige powder
          CAS number217645-70-0
          Chemical formulaC₂₁H₂₄ClFN₄O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (≥25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesShahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
          Reuss, R., et al. 2010. Mult Scler. 16, 366.
          Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
          Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
          Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.