Product Information
Applications
Biological Information
Primary TargetAEP
Purity≥98% by HPLC
Physicochemical Information
Peptide SequenceFmoc-Ala-Glu-Asn-Lys-NH2
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Asparagine Endopeptidase Inhibitor, AENK SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Zhang, Z., et al. 1999. Nat. Med. 20, 1254.
Monoury, B., et al. 1998. Nat. 396, 695.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-July-2016 JSW
SynonymsFmoc-Ala-Glu-Asn-Lys-NH2, Asparagine Endopeptidase Inhibitor, AENK, AEP Inhibitor, AENK
DescriptionAn amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).
FormWhite solid
FormulationSupplied as a TFA salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₃H₄₃N₇O₉
Peptide SequenceFmoc-Ala-Glu-Asn-Lys-NH2
Purity≥98% by HPLC
SolubilityH₂O (25 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesZhang, Z., et al. 1999. Nat. Med. 20, 1254.
Monoury, B., et al. 1998. Nat. 396, 695.

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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest