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178497 Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem

178497
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Key Specifications Table

Empirical FormulaCAS #
C₃₃H₂₄F₆N₃O₃ 1054543-47-3

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178497-10MG
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      Description
      OverviewA cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 µM).
      Catalogue Number178497
      Brand Family Calbiochem®
      SynonymsN-(4-Carboxamidobenzyl)-2-(3,5-bis-trifluoromethyl)-4,5-bis-(4-methoxyphenyl)-imidazole, Hsp70 Inhibitor III
      References
      ReferencesCho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
      Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.
      Product Information
      CAS number1054543-47-3
      FormWhite solid
      Hill FormulaC₃₃H₂₄F₆N₃O₃
      Chemical formulaC₃₃H₂₄F₆N₃O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      178497

      References

      Reference overview
      Cho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
      Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2013 JSW
      SynonymsN-(4-Carboxamidobenzyl)-2-(3,5-bis-trifluoromethyl)-4,5-bis-(4-methoxyphenyl)-imidazole, Hsp70 Inhibitor III
      DescriptionA cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 h drug treatment (1 µM). Shown to suppress ubiquitination of mutant CFTR and promote membrane trafficking, and restore chloride channel activity.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1054543-47-3
      Chemical formulaC₃₃H₂₄F₆N₃O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
      Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.