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531709 Apoptosis Activator IX, DPP-23 - Calbiochem

Apoptosis Activator IX, DPP-23 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Unfolded Protein Response Inducer, DPP-23, UPR Inducer, DPP_23

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531709
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₈H₁₈O₄
      Description
      OverviewA cell-permeable chalcone derivative that enhances the production of reactive oxygen species and reduces glutathione levels selectively in cancer cells while sparing normal cells and induces unfolded protein response (UPR) through up-regulating UPR related genes. Inhibits the growth of in multiple cancer cell lines (Capan-1, MDA-MB231, HCT116, and HT1080 cells) and suppresses the growth of HCT116 tumor xenografts in nude mice via the induction of apoptosis (10 mg/kg, i.p; q.d.). Arrests cell cycle at the G2/M phase and triggers protective autophagy and induces apoptosis by increasing the active forms of caspase 3, 7, and 9. Treatment of serum-starved MIA PaCa-2 cells with DPP-23 induces the phosphorylation of ERK1/2, JNK1/2, and p38 MAPK in a time-dependent manner.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531709
      Brand Family Calbiochem®
      SynonymsUnfolded Protein Response Inducer, DPP-23, UPR Inducer, DPP_23
      References
      ReferencesShin, Y.S., et al. 2014. Clin. Cancer Res. 20, in press.
      Product Information
      FormOff-white solid
      Hill FormulaC₁₈H₁₈O₄
      Chemical formulaC₁₈H₁₈O₄
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      531709

      Documentation

      Apoptosis Activator IX, DPP-23 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Shin, Y.S., et al. 2014. Clin. Cancer Res. 20, in press.

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products - Antibodies, Small Molecule, Inhibitors

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-December-2014 JSW
      SynonymsUnfolded Protein Response Inducer, DPP-23, UPR Inducer, DPP_23
      DescriptionA cell-permeable chalcone derivative that enhances the production of reactive oxygen species and reduces glutathione levels selectively in cancer cells while sparing normal cells and induces unfolded protein response (UPR) through up-regulating UPR related genes. Inhibits the growth of in multiple cancer cell lines (Capan-1, MDA-MB231, HCT116, and HT1080 cells) and suppresses the growth of HCT116 tumor xenografts in nude mice via the induction of apoptosis (10 mg/kg, i.p; q.d.). Arrests cell cycle at the G2/M phase and triggers protective autophagy and induces apoptosis by increasing the active forms of caspase 3, 7, and 9. Treatment of serum-starved MIA PaCa-2 cells with DPP-23 induces the phosphorylation of ERK1/2, JNK1/2, and p38 MAPK in a time-dependent manner.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₈O₄
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShin, Y.S., et al. 2014. Clin. Cancer Res. 20, in press.