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07-294-I-100UG Anti-phospho-GluR2 (Ser880)

07-294-I-100UG
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue Number07-294-I-100UG
      DescriptionAnti-phospho-GluR2 (Ser880)
      Alternate Names
      • Glutamate receptor 2
      • Glu-R2
      • AMPA-selective glutamate receptor 2
      • GluR-B
      • GluR-K2
      • Glutamate receptor ionotropic
      • AMPA 2
      • GluA2
      Background InformationGlutamate receptor 2 (UniProt: P19491; also known as GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA-selective glutamate receptor 2 AMPA 2, GluA2) is encoded by the GRIA2 (also known as GLUR2) gene (Gene ID: 296237) in rat. Glutamate receptors are synaptic receptors located primarily on the membranes of neuronal cells. These receptors play important roles in neural communication, memory formation, learning, and regulation by mediating glutamate-dependent postsynaptic excitation. Glutamate receptors are divided into two types, ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). iGluRs form ion channel pores upon glutamate binding, while mGluRs indirectly activate ion channels on the plasma membrane via G protein-coupled signaling cascade. Although all iGluRs and mGluRs bind glutamate, they do exhibit different binding activities toward chemical ligands, such as NMDA, kainate, AMPA, L-AP4, ACPD, L-QA, and such distinction is used to divide these receptors further into subtypes. Glutamate receptor 2 is an AMPA type iGluR that is initially produced with an N-terminal signal peptide sequence (aa 1-21), the removal of which yields the mature receptor with 4 transmembrane helices (aa 544-564, 592-607, 617-637, 813-833), a large N-terminal extracellular domain (aa 22-543), followed by two intracellular loops (aa 565-591, 611-616), one extracellular loop (aa 638-812) and a C-terminal cytoplasmic tail (aa 834-883). Phosphorylation of serine 880 by protein kinase C is reported to regulate the interaction of the PDZ domain-containing proteins GRIP1 and PICK 1. (Ref.: Chung, HJ., et al. (2000). J. Neurosci. 20(19); 7258-7267).
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-phospho-GluR2 (Ser880), Cat. No. 07-294-I, is a highly specific rabbit polyclonal antibody that targets Glutamate receptor 2 and has been tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated Linear Peptide corresponding to 9 amino acids surrounding phosphoserine 880 from the the C-terminal region of Rat Glutamate receptor 2.
      EpitopeC-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityAnti-phospho-GluR2 (Ser880) is a rabbit polyclonal antibody that detects glutamate receptor 2 phosphorylated on serine 880.
      IsotypeIgG
      Species Reactivity
      • Rat
      Species Reactivity NoteRat. Predicted to react with Human, Mouse, Monkey, and Chimpanzee based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FRIA2
      • GLUR2
      Modifications
      • Phosphorylation
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~110 kDa observed; 98.69 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Rat Brain Microsomal Prep with Lambda phosphatase treatment.

      Western Blotting Analysis: 2 µg/mL of this antibody detected Glutamate receptor 2 phosphorylated on Serine 880 in untreated Rat brain microsomal preparations, but not in preparations treated with Lambda phosphatase.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications