PC373 Anti-p40 (5-17) Rabbit pAb

PC373
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H Rb Polyclonal Antibody

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      PC373-1ML
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      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 1 ml
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          Description
          OverviewRecognizes the ~40 kDa p40 protein in SKOV3 cells and breast carcinoma tissue.
          Catalogue NumberPC373
          Brand Family Calbiochem®
          Application Data
          Detection of human p40 by staining paraffin sections. Sample: Human breast carcinoma. Primary antibody: Anti-p40 (5-17) Rabbit pAb (Cat. No. PC373) (1:3000). Detection: DAB with methyl green counterstain.
          References
          ReferencesHibi, K., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 5462.
          Yamaguchi, K., et al. 2000. Int. J. Cancer 86, 684.
          Hagiwara, K.,et al. 1999. Cancer Res. 59, 4165.
          Kaelin W. G. Jr. 1999. J. Natl. Cancer Inst. 91, 594.
          Osada, M., et al. 1998. Nat. Med. 7, 839.
          Senoo, M., et al. 1998. Biochem. Biophys. Res. Commun. 248, 603.
          Trink, B., et al. 1998. Nat. Med. 4, 747.
          Yang, A., et al. 1998. Mol. Cell 2, 305.
          Product Information
          FormLiquid
          FormulationUndiluted serum.
          Positive controlSKOV3 cells or breast carcinoma tissue
          PreservativeNone
          Applications
          Key Applications Immunoblotting (Western Blotting)
          Not Immunofluorescence
          Paraffin Sections
          Application NotesImmunoblotting (1:500, chemiluminescence)
          Paraffin Sections (1:3000, heat pre-treatment required)
          Application CommentsAntibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogena synthetic peptide corresponding to amino acids 5-17 of human p40
          ImmunogenHuman
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • Human
          Antibody TypePolyclonal Antibody
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Anti-p40 (5-17) Rabbit pAb SDS

          Title

          Safety Data Sheet (SDS) 

          Anti-p40 (5-17) Rabbit pAb Certificates of Analysis

          TitleLot Number
          PC373

          References

          Reference overview
          Hibi, K., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 5462.
          Yamaguchi, K., et al. 2000. Int. J. Cancer 86, 684.
          Hagiwara, K.,et al. 1999. Cancer Res. 59, 4165.
          Kaelin W. G. Jr. 1999. J. Natl. Cancer Inst. 91, 594.
          Osada, M., et al. 1998. Nat. Med. 7, 839.
          Senoo, M., et al. 1998. Biochem. Biophys. Res. Commun. 248, 603.
          Trink, B., et al. 1998. Nat. Med. 4, 747.
          Yang, A., et al. 1998. Mol. Cell 2, 305.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-October-2007 RFH
          ApplicationImmunoblotting (1:500, chemiluminescence)
          Paraffin Sections (1:3000, heat pre-treatment required)
          Application Data
          Detection of human p40 by staining paraffin sections. Sample: Human breast carcinoma. Primary antibody: Anti-p40 (5-17) Rabbit pAb (Cat. No. PC373) (1:3000). Detection: DAB with methyl green counterstain.
          DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~40 kDa p40 protein.
          BackgroundAmong the more recently identified p53 homologues are p73 and p40/p63/p73L/p51/CUSP/KET. Existing as two splice variants with molecular weights of ~51 kDa and ~72 kDa, the p40 gene product is essential for normal epithelial development. The gene maps to the distal arm of chromosome 3q and is mutated in a diverse number of human cancers. The p40 gene is expressed in skeletal muscle, placenta, mammary gland, prostate, trachea, thymus, salivary gland, uterus, heart and lung. The p40 protein has the ability to transactivate many p53 reporter genes and also has the ability to induce apoptosis.
          HostRabbit
          Immunogen speciesHuman
          Immunogena synthetic peptide corresponding to amino acids 5-17 of human p40
          IsotypeIgG
          Specieshuman, not mouse
          Positive controlSKOV3 cells or breast carcinoma tissue
          FormLiquid
          FormulationUndiluted serum.
          PreservativeNone
          CommentsAntibody should be titrated for optimal results in individual systems.
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesHibi, K., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 5462.
          Yamaguchi, K., et al. 2000. Int. J. Cancer 86, 684.
          Hagiwara, K.,et al. 1999. Cancer Res. 59, 4165.
          Kaelin W. G. Jr. 1999. J. Natl. Cancer Inst. 91, 594.
          Osada, M., et al. 1998. Nat. Med. 7, 839.
          Senoo, M., et al. 1998. Biochem. Biophys. Res. Commun. 248, 603.
          Trink, B., et al. 1998. Nat. Med. 4, 747.
          Yang, A., et al. 1998. Mol. Cell 2, 305.