MABN352 Anti-delta-type Opioid Receptor, clone 4E6.2 Antibody

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MABN352
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M IH(P), WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABN352
      DescriptionAnti-delta-type Opioid Receptor, clone 4E6.2 Antibody
      Alternate Names
      • Delta-type opioid receptor
      • D-OR-1
      • DOR-1
      Background InformationDelta-type Opioid Receptor (D-OR-1), also known as DOR-1, and encoded by the gene name OPRD1/ OPRD, is a G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Binding of Delta-type Opioid Receptor with ligands causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Delta-type Opioid Receptor signaling has been shown to lead to the inhibition of adenylate cyclase activity. Recent studies have also demonstrated that Delta-type Opioid Receptor inhibits the neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Delta-type Opioid Receptor also may play a role in the perception of pain and in opiate-mediated analgesia. Additionally, it may play a role in developing analgesic tolerance to morphine, and it may form homooligomers. Delta-type Opioid Receptor interacts with GPRASP1. Delta-type Opioid Receptor is detected in oocytes (at protein level), and in brain cortex, hypothalamus, hippocampus and olfactory bulb.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-delta-type Opioid Receptor antibody is validated for use in WB, IH(P) for the detection of delta-type Opioid Receptor.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected delta-type Opioid Receptor in human cerebral cortex, human uterus, and human thalamus tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of human delta-type Opioid Receptor.
      EpitopeC-terminus
      Clone4E6.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OPRD1
      • OPRD
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~65 kDa observed. The calculated molecular weight of this protein is 40 kDa, but can be observed at ~65 kDa due to high glycosylation.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected delta-type Opioid Receptor in 10 µg of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-delta-type Opioid Receptor, clone 4E6.2 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-delta-type Opioid Receptor, clone 4E6.2 Antibody Certificates of Analysis

      TitleLot Number
      Anti-delta-type Opioid Receptor, clone -27894062789406
      Anti-delta-type Opioid Receptor, clone 4E6.2Q2484133
      Anti-delta-type Opioid Receptor, clone 4E6.2 - 31886403188640
      Anti-delta-type Opioid Receptor, clone 4E6.2 -28595412859541
      Anti-delta-type Opioid Receptor, clone 4E6.2 Monoclonal Antibody2955683
      Anti-delta-type Opioid Receptor, clone 4E6.2 Monoclonal Antibody3028087
      Anti-delta-type Opioid Receptor, clone 4E6.2 Monoclonal Antibody3153342

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies