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07-1497 Anti-cAMP Antibody

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07-1497
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIH(P)RbSerumPolyclonal Antibody
      Description
      Catalogue Number07-1497
      ReplacesMABN1026
      DescriptionAnti-cAMP Antibody
      Background InformationCyclic adenosine monophosphate or cAMP is an intracellular by-product of ATP by adenylene cyclase when G-protein Coupled Receptors (GPCR) bind various ligands on the cell surface. Cyclic AMP acts as a second messenger for signal transduction across the cell membrane and is a part of kinase activation. It regulates the effects of glucagon and adrenaline along with the movement of calcium ions through ion channels. Since it is affected directly by GPCR activation, cAMP is studied as a means to monitor GPCR in the discovery of therapeutic drugs.
      References
      Product Information
      FormatSerum
      Control
      • Rat hippocampus and cerebellum tissue
      PresentationDiluted serum presented as liquid in PBS containing no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-cAMP Antibody detects level of cAMP & has been published & validated for use in IH(P).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      Immunogen2'O-succinyl cyclic AMP conjugated to BSA
      HostRabbit
      SpecificitySpecific for cAMP with no cross reaction to other nucleotides at concentrations to 1 mM. Reactive with cAMP fixed in tissues or acetylated cAMP. Not reactive with free, non-acetylated, cAMP in RIA or EIA assays.
      Species Reactivity
      • Rat
      Species Reactivity NoteProven to react with rat. Expected to react with all species.
      Antibody TypePolyclonal Antibody
      Purification MethodUnpurified rabbit serum
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in rat hippocampus and cerebellum tissue.
      Immunohistochemistry Analysis: 1:100 dilution of this lot detected cAMP in rat hippocampus and cerebellum tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots from date of shipment. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-cAMP Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-cAMP Antibody Certificates of Analysis

      TitleLot Number
      Anti-cAMP - 2441917 2441917
      Anti-cAMP - 1996268 1996268
      Anti-cAMP - 2197309 2197309
      Anti-cAMP - 2492788 2492788
      Anti-cAMP - 3202271 3202271
      Anti-cAMP - 3321125 3321125
      Anti-cAMP - 3484052 3484052
      Anti-cAMP - 3724693 3724693
      Anti-cAMP - NG1753066 NG1753066
      Anti-cAMP - NG1800893 NG1800893

      References

      Reference overviewApplicationSpeciesPub Med ID
      Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells.
      Luo, Q; Kumar, P; Vickers, TJ; Sheikh, A; Lewis, WG; Rasko, DA; Sistrunk, J; Fleckenstein, JM
      Infection and immunity  82  509-21  2014

      Show Abstract
      ImmunohistochemistryMouse24478067 24478067