Millipore Sigma Vibrant Logo

MAB3729 Anti-c-met Antibody, clone 4AT44

View Products on Sigmaaldrich.com
MAB3729
400 µl  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB3729
      Replaces04-1051
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-c-met Antibody, clone 4AT44
      Alternate Names
      • Hepatocyte Growth Factor Receptor
      • HGFR
      References
      Product Information
      FormatPurified
      PresentationProtein G purified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-c-met Antibody, clone 4AT44 is validated for use in WB for the detection of c-met.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot: 1:100-1:500.

      ELISA (direct): 1:1,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPurified recombinant catalytic domain of human Met
      Clone4AT44
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with c-met/HGFR (Hepatocyte growth factor receptor). The Met receptor tyrosine kinase is the prototypical member of a small subfamily of growth factor receptors that when activated, induces mitogenic, motogenic, and morphogenic cellular responses. The ligand for c-met is hepatocyte growth factor/scatter factor (HGF/SF) and while normal HGF/SF-Met signaling is required for embryonic development, abnormal c-met signaling has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size400 µl
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-c-met Antibody, clone 4AT44 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-c-met Antibody, clone 4AT44 Certificates of Analysis

      TitleLot Number
      Anti-c-met, clone 4AT44 - 32483923248392
      Anti-c-met, clone 4AT44 -25548462554846
      Anti-c-met, clone 4AT44 -25806872580687
      Anti-c-met, clone 4AT44 -26891522689152
      Anti-c-met, clone 4AT44 Monoclonal Antibody3033932
      Anti-c-met, clone 4AT44 Monoclonal Antibody3131885
      MOUSE ANTI-MET/HGFR MONOCLONAL ANTIBODY - 21209472120947
      MOUSE ANTI-MET/HGFR MONOCLONAL ANTIBODY - 20438732043873
      MOUSE ANTI-MET/HGFR MONOCLONAL ANTIBODY - 21989402198940

      References

      Reference overviewPub Med ID
      Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
      Buraschi, S; Pal, N; Tyler-Rubinstein, N; Owens, RT; Neill, T; Iozzo, RV
      The Journal of biological chemistry  285  42075-85  2010

      Show Abstract Full Text Article
      20974860 20974860
      A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings.
      Knudsen, BS; Zhao, P; Resau, J; Cottingham, S; Gherardi, E; Xu, E; Berghuis, B; Daugherty, J; Grabinski, T; Toro, J; Giambernardi, T; Skinner, RS; Gross, M; Hudson, E; Kort, E; Lengyel, E; Ventura, A; West, RA; Xie, Q; Hay, R; Vande Woude, G; Cao, B
      Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry  17  57-67  2009

      Show Abstract Full Text Article
      18815565 18815565
      Antibody validation by quantitative analysis of protein expression using expression of Met in breast cancer as a model.
      Pozner-Moulis, S; Cregger, M; Camp, RL; Rimm, DL
      Laboratory investigation; a journal of technical methods and pathology  87  251-60  2007

      Show Abstract
      17260003 17260003

      Data Sheet

      Title
      MOUSE ANTI-MET/HGFR MONOCLONAL ANTIBODY

      Related Products & Applications

      Related Products

      Catalog Number Description  
      05-900 Anti-phospho-Met (Tyr1234/1235) Antibody, clone NL8, rabbit monoclonal Show Pricing & Availability
      07-211 Anti-phospho-Met (Tyr1234/1235) Antibody Show Pricing & Availability
      07-2242 Anti-phospho-c-Met (Tyr1230/1234/1235) Antibody Show Pricing & Availability
      07-807 Anti-phospho-Met (Tyr1003) Antibody Show Pricing & Availability
      07-808 Anti-phospho-Met (Tyr1349) Antibody Show Pricing & Availability
      07-810 Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody Show Pricing & Availability
      MAB3731 Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877 Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies