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36-008-C Anti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free)

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36-008-C
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number36-008-C
      DescriptionAnti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free)
      Alternate Names
      • Alpha-synuclein
      • Non-A beta component of AD amyloid
      • Non-A4 component of amyloid precursor
      • NACP
      Background InformationAlpha-synuclein is encoded by the SNCA gene (also known as NACP, PARK1) in human. There are two other known synuclein family members, beta- and gamma-synuclein. Interest in synuclein research started with the discovery of alpha-synuclein mutation in several families with autosomal dominant Parkinson's disease (PD). Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of PD. The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes. Contradictory evidences regarding inhibitory action of alpha-synuclein against phospholipase D (PLD) have been reported (PMID 11821392 & 19146388). Clone Syn211, Cat. No. 36-008-C detects epitope in the region from amino acid 121 to 125 and has been used together with clone LB509, Cat. No. MABN824, to characterize the digestion pattern of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free) is an antibody against alpha-Synuclein for use in Immunohistochemistry and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected alpha-Synuclein in human cerebral cortex and human kidney tissue.
      Western Blotting Analysis: A representative lot detected alpha-Synuclein in Synucleinopathy brains (Guo, J.L., et al. (2013). Cell. 154:103-117).
      Biological Information
      ImmunogenConjugated recombinant protein corresponding to human alpha-Synuclein.
      Epitopealpha-syn 121-125
      CloneSyn211
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SNCA
      • NACP
      • PARK1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~15 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected alpha-Synuclein in 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°Cfrom date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      36-008-C 04055977161922

      Documentation

      Anti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free) Certificates of Analysis

      TitleLot Number
      Anti-alpha-Synuclein (aa 121-125) , -Q2559153 Q2559153
      Anti-alpha-Synuclein (aa 121-125) , clone Syn211 (Ascites Free) - 3207662 3207662
      Anti-alpha-Synuclein (aa 121-125) , clone Syn211 (Ascites Free) Monoclonal Antibody 3143112
      Anti-alpha-Synuclein (aa 121-125), clone Syn211 (Ascites Free) Monoclonal Antibody 3099946
      Anti-alpha-Synuclein (aa 121-125), clone Syn211 (Ascites Free) Monoclonal Antibody 3040392

      References

      Reference overviewPub Med ID
      Distinct α-synuclein strains differentially promote tau inclusions in neurons.
      Guo, JL; Covell, DJ; Daniels, JP; Iba, M; Stieber, A; Zhang, B; Riddle, DM; Kwong, LK; Xu, Y; Trojanowski, JQ; Lee, VM
      Cell  154  103-17  2013

      Show Abstract
      23827677 23827677

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies