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AB4340 Anti-Zscan4 Antibody

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100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IF, IPRbAffinity PurifiedPolyclonal Antibody
      Catalogue NumberAB4340
      DescriptionAnti-Zscan4 Antibody
      Alternate Names
      • Zinc finger and SCAN domain containing protein 4C
      Background InformationZinc finger and SCAN domain containing protein 4, also called Zscan4, is an embryonic stem (ES) cell-specific transcription factor required to regulate pluripotency. Zscan4 binds and regulates telomere elongation in order to maintain genomic stability and acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) in undifferentiated ES cells.
      Product Information
      FormatAffinity Purified
      • Embryonic Stem Cell lysates
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      ApplicationAnti-Zscan4 Antibody is a highly specific rabbit polyclonal antibody, that targets Zinc Finger Protein & has been tested in western blotting, Immunofluorescence & IP.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      • Immunoprecipitation
      Application NotesImmunofluorescence Analysis: A 1:1,000 dilution from a representative lot detected Zscan4 in mouse iPS and R1 Embyonic Stem cells. Data courtesy of the Melanie Welham lab at The University of Bath, UK
      Immunoprecipitation Analysis: A 1:4,000 dilution from a representative lot detected Zscan4 in cytoplasmic and nuclear extracts in IP experiments conducted by the Melanie Welham lab at The University of Bath, UK. (Data not shown)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to mouse Zscan4.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Zscan4c
      • Gm397
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~65 kDa observed. The calculated molecular weight of this protein is 57 kDa. An uncharacterized band may be observed at ~50 kDa in some cell lysates.ZSCAN4 bands may be observed at both ~72 kDa and ~40 kDa when preparing cell lysates with SDS buffer. Additionally, a ZSCAN4 doublet may be observed at ~72 kDa when using cytosolic or nuclear extracts.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse Embryonic Stem cell lysates.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected Zscan4 in 10 µg of Embryonic Stem cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information


      Anti-Zscan4 Antibody SDS


      Safety Data Sheet (SDS) 

      Anti-Zscan4 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Zscan4 3082492
      Anti-Zscan4 - Q2144996 Q2144996
      Anti-Zscan4 - 2520373 2520373
      Anti-Zscan4 - 3200630 3200630
      Anti-Zscan4 - 3385852 3385852
      Anti-Zscan4 - 3690683 3690683
      Anti-Zscan4 - 3807973 3807973
      Anti-Zscan4 - 3905048 3905048
      Anti-Zscan4 - 3924044 3924044
      Anti-Zscan4 - 4005693 4005693


      Reference overviewPub Med ID
      Role of Tet proteins in enhancer activity and telomere elongation.
      Lu, F; Liu, Y; Jiang, L; Yamaguchi, S; Zhang, Y
      Genes & development  28  2103-19  2014

      Show Abstract
      25223896 25223896
      Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells.
      Storm, MP; Kumpfmueller, B; Bone, HK; Buchholz, M; Sanchez Ripoll, Y; Chaudhuri, JB; Niwa, H; Tosh, D; Welham, MJ
      PloS one  9  e89821  2014

      Show Abstract
      24594919 24594919