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AB5905 Anti-Vesicular Glutamate Transporter 1 Antibody

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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIHCGpSerumPolyclonal Antibody
      Catalogue NumberAB5905
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Vesicular Glutamate Transporter 1 Antibody
      Alternate Names
      • VGLUT1
      • BNPI
      Background InformationVGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate. Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate.
      Product Information
      • Rat brain lysate
      PresentationGuinea pig Serum in 0.1% Sodium Azide.
      Quality LevelMQ100
      ApplicationThis Anti-Vesicular Glutamate Transporter 1 Antibody is validated for use in Immunohistochemistry for the detection of Vesicular Glutamate Transporter 1 with more than 55 product citations.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:5,000-1:10,000 using a cyanine conjugated secondary antibody.

      Lightly fixed 4% PFA fixed materials are recommended. Enzymatic detection requires substantially higher primary antibody dilutions.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide from rat VGLUT1 protein with no overlap to VGLUT2. The immunogen is available as AG208.
      HostGuinea Pig
      SpecificityRecognizes Vesicular Glutamate Transporter 1 (VGLUT1, BNPI {Brain specific Na+ dependent inorganic phosphate cotransporter}). The antiserum has been tested on tissue sections from the rat central nervous system (CNS) using immunofluorescence histochemistry. The antiserum mainly labels nerve fibers and terminals. VGLUT1 is an excellent marker for glutamatergic nerve terminals. The staining pattern for the staining obtained with the VGLUT1 antiserum corresponds to the pattern described using other antisera to VGLUT1 (Bellocchio et al., 1998; Fremeau et al., 2001; Fujiyama et al., 2001; Sakata-Haga et al., 2001; Tong et al., 2001; Kaneko et al. 2002; Varoqui et al., 2002). Preabsorption of the VGLUT1 antiserum with immunogen peptide eliminates all immunostaining.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene Summarya Na(+)-dependent inorganic phosphate cotransporter.
      Gene Symbol
      • VGluT1
      • Solute carrier family 17 member 7
      • Brain-specific Na(+)-dependent inorganic phosphate cotransporter
      • Slc17a7
      • Bnpi
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
      SIZE: 560 amino acids; 61665 Da [MW of unprocessed precursor]
      SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome.
      TISSUE SPECIFICITY: Expressed in the cerebellum, cerberal cortex and hippocampus. Isoform 2 is expressed specifically in retina.
      SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
      Molecular Weight62 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 6 months at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information


      Anti-Vesicular Glutamate Transporter 1 Antibody SDS


      Safety Data Sheet (SDS) 

      Anti-Vesicular Glutamate Transporter 1 Antibody Certificates of Analysis

      TitleLot Number
      Anti-VGLUT1 - 2370733 2370733
      Anti-VGLUT1 - 2387528 2387528
      Anti-VGLUT1 - 2430498 2430498
      Anti-VGLUT1 - 2455644 2455644
      Anti-VGLUT1 - 3193844 3193844
      Anti-VGLUT1 - 3258729 3258729
      Anti-VGLUT1 - 3308226 3308226
      Anti-VGLUT1 - 3478256 3478256
      Anti-VGLUT1 - 3616495 3616495
      Anti-VGLUT1 - 3756537 3756537


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      Peng, X; Hughes, EG; Moscato, EH; Parsons, TD; Dalmau, J; Balice-Gordon, RJ
      Annals of neurology  77  381-98  2015

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      Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.
      Brigidi, GS; Santyr, B; Shimell, J; Jovellar, B; Bamji, SX
      Nature communications  6  8200  2015

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      Aberrant synaptic integration in adult lamina I projection neurons following neonatal tissue damage.
      Li, J; Kritzer, E; Craig, PE; Baccei, ML
      The Journal of neuroscience : the official journal of the Society for Neuroscience  35  2438-51  2015

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      Loss of δ-catenin function in severe autism.
      Turner, TN; Sharma, K; Oh, EC; Liu, YP; Collins, RL; Sosa, MX; Auer, DR; Brand, H; Sanders, SJ; Moreno-De-Luca, D; Pihur, V; Plona, T; Pike, K; Soppet, DR; Smith, MW; Cheung, SW; Martin, CL; State, MW; Talkowski, ME; Cook, E; Huganir, R; Katsanis, N; Chakravarti, A
      Nature  520  51-6  2015

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      Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.
      Puccini, JM; Marker, DF; Fitzgerald, T; Barbieri, J; Kim, CS; Miller-Rhodes, P; Lu, SM; Dewhurst, S; Gelbard, HA
      The Journal of neuroscience : the official journal of the Society for Neuroscience  35  5271-83  2015

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      Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors.
      Fleming, MS; Vysochan, A; Paixão, S; Niu, J; Klein, R; Savitt, JM; Luo, W
      eLife  4  e06828  2015

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      Mapping synapses by conjugate light-electron array tomography.
      Collman, F; Buchanan, J; Phend, KD; Micheva, KD; Weinberg, RJ; Smith, SJ
      The Journal of neuroscience : the official journal of the Society for Neuroscience  35  5792-807  2015

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      Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity.
      Atkin, G; Moore, S; Lu, Y; Nelson, RF; Tipper, N; Rajpal, G; Hunt, J; Tennant, W; Hell, JW; Murphy, GG; Paulson, H
      The Journal of neuroscience : the official journal of the Society for Neuroscience  35  6165-78  2015

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      Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood.
      Risher, ML; Fleming, RL; Risher, WC; Miller, KM; Klein, RC; Wills, T; Acheson, SK; Moore, SD; Wilson, WA; Eroglu, C; Swartzwelder, HS
      Alcoholism, clinical and experimental research  39  989-97  2015

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      Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
      Paşca, AM; Sloan, SA; Clarke, LE; Tian, Y; Makinson, CD; Huber, N; Kim, CH; Park, JY; O'Rourke, NA; Nguyen, KD; Smith, SJ; Huguenard, JR; Geschwind, DH; Barres, BA; Paşca, SP
      Nature methods  12  671-8  2015

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