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MABN504 Anti-VDAC1 Antibody, clone N152B/23

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHCMPurifiedMonoclonal Antibody
      Catalogue NumberMABN504
      DescriptionAnti-VDAC1 Antibody, clone N152B/23
      Alternate Names
      • Voltage-dependent anion-selective channel protein 1
      • VDAC-1
      • hVDAC1
      • Outer mitochondrial membrane protein porin 1
      • Plasmalemmal porin
      • Porin 31HL
      • Porin 31HM
      Background InformationVoltage-dependent anion-selective channel protein 1 (VDAC1, VDAC), also known as outer mitochondrial membrane protein porin 1, is the outer mitochondrial membrane receptor for hexokinase and BCL2L1. VDAC1 forms a channel through the mitochondrial membrane and is involved in small molecule diffusion, cell volume regulation and apoptosis. VDAC1 may participate in the formation of the permeability transition pore complex (PTPC), which is responsible for the release of mitochondrial products that triggers apoptosis.
      Product Information
      • Mouse brain tissue lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      ApplicationDetect VDAC using this mouse monoclonal antibody, Anti-VDAC1 Antibody, clone N152B/23 validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: A representative lot states VDAC1 does not cross-react with VDAC2 or VDAC3 (based on KO validation results) representative lot deteted VDAC1 in wild type mouse liver tissue, and demonstrated a loss of signal in VDAC1 knock out mouse hippocampal tissue using immunobloting analysis (Prof. J. Trimmer, University of California, Davis).
      Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected VDAC1 in human cardiac myocytes tissue.
      Biological Information
      ImmunogenRecombinant protein corresponding to human VDAC1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody does not cross-react with VDAC2 or VDAC3 (Prof. J. Trimmer, University of California, Davis).
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • VDAC1
      • VDAC
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~ 35 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected VDAC1 in 10 µg of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information


      Anti-VDAC1 Antibody, clone N152B/23 SDS


      Safety Data Sheet (SDS) 

      Anti-VDAC1 Antibody, clone N152B/23 Certificates of Analysis

      TitleLot Number
      ANTI-VDAC1, clone N152B/23 2480975
      ANTI-VDAC1, clone N152B/23 (mouse monoclonal) Monoclonal Antibody Q2925515
      ANTI-VDAC1, clone N152B/23 - 2428360 2428360
      ANTI-VDAC1, clone N152B/23 - 2433605 2433605
      ANTI-VDAC1, clone N152B/23 - 3168286 3168286
      ANTI-VDAC1, clone N152B/23 - 3445077 3445077
      ANTI-VDAC1, clone N152B/23 - 3786036 3786036
      ANTI-VDAC1, clone N152B/23 - Q2187171 Q2187171
      ANTI-VDAC1, clone N152B/23 -2580720 2580720
      ANTI-VDAC1, clone N152B/23 -2601731 2601731


      Reference overviewPub Med ID
      Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels.
      Mourier, A; Motori, E; Brandt, T; Lagouge, M; Atanassov, I; Galinier, A; Rappl, G; Brodesser, S; Hultenby, K; Dieterich, C; Larsson, NG
      The Journal of cell biology  208  429-42  2015

      Show Abstract
      25688136 25688136