AB5423 Anti-Tyrosine Hydroxylase Antibody, phosphoSer31

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AB5423
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R ICC, IHC, WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB5423
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Tyrosine Hydroxylase Antibody, phosphoSer31
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Tyrosine Hydroxylase Antibody, phosphoSer31 is validated for use in IC, IH, WB for the detection of Tyrosine Hydroxylase.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1:1,000

      Immunocytochemistry: 1:1,000

      Immunohistochemistry: 1:1,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from the phosphoSer31 of rat Tyrosine Hydroxylase. Available as catalog number AG398
      EpitopephosphoSer31
      HostRabbit
      SpecificityTyrosine Hydroxylase, phosphoSer31. The antibody recognizes a protein of 60 kDa corresponding to TH phosphorylated at Ser31 in lysates of PC-12 cells stimulated by okadaic acid.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryTyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.
      Gene Symbol
      • TH
      • TYH
      • EC 1.14.16.2
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.
      COFACTOR: Fe(2+) ion.
      SIZE: 528 amino acids; 58524 Da
      TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.
      DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.
      SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Tyrosine Hydroxylase Antibody, phosphoSer31 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Tyrosine Hydroxylase Antibody, phosphoSer31 Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-TYROSINE HYDROXYLASE phosphoSer31 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 23825872382587
      RABBIT ANTI-TYROSINE HYDROXYLASE phosphoSer31 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 24627192462719
      RABBIT ANTI-TYROSINE HYDROXYLASE phosphoSer31 - 32119263211926
      RABBIT ANTI-TYROSINE HYDROXYLASE phosphoSer31 -26394512639451
      RABBIT ANTI-TYROSINE HYDROXYLASE phosphoSer31 -27597202759720
      RABBIT ANTI-TYROSINE HYDROXYLASE phosphoSer31 -28546482854648
      RABBIT ANTI-TYROSINE HYDROXYLASE phosphoSer31 AFFINITY PURIFIED2483175
      RABBIT ANTI-TYROSINE HYDROXYLASE phosphoSer31 AFFINITY PURIFIED POLYCLONAL ANTIBODY2935540
      RABBIT ANTI-TYROSINE HYDROXYLASE phosphoSer31 AFFINITY PURIFIED POLYCLONAL ANTIBODY3152203
      RABBIT ANTI-TYROSINE HYDROXYLASE phosphoSer31 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 19909201990920

      References

      Reference overviewApplicationPub Med ID
      Crosstalk between G protein-coupled receptors (GPCRs) and tyrosine kinase receptor (TXR) in the heart after morphine withdrawal.
      Almela, P; García-Carmona, JA; Martínez-Laorden, E; Milanés, MV; Laorden, ML
      Frontiers in pharmacology  4  164  2013

      Show Abstract
      Western Blotting24409147 24409147
      Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc).
      Almela, P; Navarro-Zaragoza, J; García-Carmona, JA; Mora, L; Hidalgo, J; Milanés, MV; Laorden, ML
      PloS one  7  e47089  2012

      Show Abstract
      Western Blotting23071721 23071721
      Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA).
      Di Cara, B; Maggio, R; Aloisi, G; Rivet, JM; Lundius, EG; Yoshitake, T; Svenningsson, P; Brocco, M; Gobert, A; De Groote, L; Cistarelli, L; Veiga, S; De Montrion, C; Rodriguez, M; Galizzi, JP; Lockhart, BP; Cogé, F; Boutin, JA; Vayer, P; Verdouw, PM; Groenink, L; Millan, MJ
      The Journal of neuroscience : the official journal of the Society for Neuroscience  31  16928-40  2011

      Show Abstract
      Western Blotting22114263 22114263
      Phenotype of neurons in the nucleus of the solitary tract that express CCK-induced activation of the ERK signaling pathway.
      Babic, T; Townsend, RL; Patterson, LM; Sutton, GM; Zheng, H; Berthoud, HR
      American journal of physiology. Regulatory, integrative and comparative physiology  296  R845-54  2009

      Show Abstract
      19176891 19176891
      Dopaminergic system dysregulation in the mrsk2_KO mouse, an animal model of the Coffin-Lowry syndrome.
      Marques Pereira, P; Gruss, M; Braun, K; Foos, N; Pannetier, S; Hanauer, A
      Journal of neurochemistry  1325-34  2008

      Show Abstract
      Immunoblotting (Western)18823370 18823370
      Activity-dependent phosphorylation of tyrosine hydroxylase in dopaminergic neurons of the rat retina.
      Witkovsky, Paul, et al.
      J. Neurosci., 24: 4242-9 (2004)  2004

      Show Abstract
      15115820 15115820
      Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds.
      Salvatore, M F, et al.
      J. Neurochem., 75: 225-32 (2000)  2000

      Show Abstract
      10854265 10854265

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies