MAB318-AF488 Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate

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MAB318-AF488
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Zebrafish, Ch, Fg, H, M, R ICC M AlexaFluor®488 Monoclonal Antibody
      Description
      Catalogue NumberMAB318-AF488
      DescriptionAnti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate
      Alternate Names
      • Tyrosine 3-monooxygenase
      • Tyrosine Hydroxylase
      • Tyrosine 3-hydroxylase
      • TH
      Background InformationTyrosine 3-monooxygenase (EC 1.14.16.2; UniProt P07101; also known as Dystonia 14, TH, Tyrosine 3-hydroxylase) is encoded by the TH (also known as DYT14, DYT5b, TYH) gene (Gene ID 7054) in human. Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. TH enzymatic activity requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. Six isoforms of human TH exist as a result of alternative splicing (UniProt P07101-1 through P07101-6).
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified mouse antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate is an antibody against Tyrosine Hydroxylase for use in Immunocytochemistry.
      Key Applications
      • Immunocytochemistry
      Application NotesThe unconjugated antibody (Cat. No. MAB318) is shown to be suitable also for Western blotting, immunohistochemistry, and immunoprecipitation applications.
      Biological Information
      ImmunogenTyrosine Hydroxylase purified from PC12 cells.
      EpitopeOn the outside of the regulatory N-terminus of tyrosine hydroxylase.
      CloneLNC1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityRecognizes an epitope on the outside of the regulatory N-terminus of tyrosine hydroxylase. Does not react with dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase, or phenethanolamine-N-methyl transferase (PNMT) by Western blotting using the unconjugated antibody (Cat. No. MAB318).
      IsotypeIgG1κ
      Species Reactivity
      • Zebrafish
      • Chicken
      • Frog
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TH
      • TYH
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight~59-63 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in rat cortical neurons.

      Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Tyrosine Hydroxylase in rat cortical neurons.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate Certificates of Analysis

      TitleLot Number
      Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate -28888162888816
      Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 30114793011479
      Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 31856173185617
      Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 32319353231935
      Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 33362343336234
      Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate -28271332827133
      Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate -Q2630870Q2630870
      Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate Monoclonal Antibody3091909
      Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate Monoclonal Antibody2865894
      Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate Monoclonal Antibody2868342

      Brochure

      Title
      Neuroscience Solutions for productive research

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies