AB5986P Anti-Tyrosine Hydroxylase Antibody

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AB5986P
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IHC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB5986P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Tyrosine Hydroxylase Antibody
      Alternate Names
      • TH
      • Tyrosine Monooxygenase
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin.
      Quality LevelMQ100
      Applications
      ApplicationDetect Tyrosine Hydroxylase using this Anti-Tyrosine Hydroxylase Antibody validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 0.5-1.0 μg/mL.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids 32-47 of rat Tyrosine Hydroxylase.
      HostRabbit
      SpecificityTyrosine Hydroxylase. Immunohistochemical distribution throughout the brain shows that staining is restricted to those neurons known to contain the enzyme. The antibody has proven useful in staining catecholaminergic neurons. AB5986 stains these neurons intensely, including dendritic processes and fine nerve terminals.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryTyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.
      Gene Symbol
      • TH
      • TYH
      • EC 1.14.16.2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.
      COFACTOR: Fe(2+) ion.
      SIZE: 528 amino acids; 58524 Da
      TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.
      DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.
      SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Tyrosine Hydroxylase Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Tyrosine Hydroxylase Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-TYROSINE HYDROXYLASE -26341882634188
      RABBIT ANTI-TYROSINE HYDROXYLASE -26376742637674
      RABBIT ANTI-TYROSINE HYDROXYLASE AFFINITY PURIFIED POLYCLONAL ANTIBODY2939720
      RABBIT ANTI-TYROSINE HYDROXYLASE AFFINITY PURIFIED POLYCLONAL ANTIBODY - 20808232080823
      RABBIT ANTI-TYROSINE HYDROXYLASE AFFINITY PURIFIED POLYCLONAL ANTIBODY - 22801962280196

      References

      Reference overviewPub Med ID
      The brain pattern of c-fos induction by two doses of amphetamine suggests different brain processing pathways and minor contribution of behavioural traits.
      D Rotllant,C Márquez,R Nadal,A Armario
      Neuroscience  168  2010

      Show Abstract
      20406670 20406670
      Immunohistochemical studies on phosphorylation of tyrosine hydroxylase in central catecholamine neurons using site- and phosphorylation state-specific antibodies.
      Xu, Z Q, et al.
      Neuroscience, 82: 727-38 (1998)  1998

      Show Abstract
      9483531 9483531
      Antibodies to a segment of tyrosine hydroxylase phosphorylated at serine 40.
      Goldstein, M, et al.
      J. Neurochem., 64: 2281-7 (1995)  1995

      Show Abstract
      7722513 7722513
      Antibodies to a synthetic peptide corresponding to a Ser-40-containing segment of tyrosine hydroxylase: activation and immunohistochemical localization of tyrosine hydroxylase.
      Lee, K Y, et al.
      J. Neurochem., 53: 1238-44 (1989)  1989

      Show Abstract
      2570128 2570128

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      Alternative Format

      Catalog Number Description  
      AB5986 Anti-Tyrosine Hydroxylase Antibody Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies