AB5986 Anti-Tyrosine Hydroxylase Antibody

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AB5986
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IHC Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB5986
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Tyrosine Hydroxylase Antibody
      Alternate Names
      • TH
      • Tyrosine Monooxygenase
      References
      Product Information
      FormatSerum
      Control
      • POSITIVE CONTROL: brain (sympathetic nerve terminals) and adrenal glands.
      PresentationRabbit serum. Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Tyrosine Hydroxylase Antibody is validated for use in IH for the detection of Tyrosine Hydroxylase.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:2,000-1:4,000.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids 32-47 of rat Tyrosine Hydroxylase.
      HostRabbit
      SpecificityTyrosine Hydroxylase. Immunohistochemical distribution throughout the brain shows that staining is restricted to those neurons known to contain the enzyme. The antibody has proven useful in staining catecholaminergic neurons. AB5986 stains these neurons intensely, including dendritic processes and fine nerve terminals.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryTyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.
      Gene Symbol
      • TH
      • TYH
      • EC 1.14.16.2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.
      COFACTOR: Fe(2+) ion.
      SIZE: 528 amino acids; 58524 Da
      TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.
      DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.
      SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material frozen at -20°C to -70°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Tyrosine Hydroxylase Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Tyrosine Hydroxylase Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-TYROSINE HYDROXYLASE - 25584112558411
      RABBIT ANTI-TYROSINE HYDROXYLASE - 32495453249545
      RABBIT ANTI-TYROSINE HYDROXYLASE - 34391893439189
      RABBIT ANTI-TYROSINE HYDROXYLASE -27831182783118
      RABBIT ANTI-TYROSINE HYDROXYLASE POLYCLONAL ANTIBODY2978935
      RABBIT ANTI-TYROSINE HYDROXYLASE POLYCLONAL ANTIBODY - 19882681988268
      RABBIT ANTI-TYROSINE HYDROXYLASE POLYCLONAL ANTIBODY - 20296132029613
      RABBIT ANTI-TYROSINE HYDROXYLASE POLYCLONAL ANTIBODY - 20497652049765
      RABBIT ANTI-TYROSINE HYDROXYLASE POLYCLONAL ANTIBODY - 20693482069348
      RABBIT ANTI-TYROSINE HYDROXYLASE POLYCLONAL ANTIBODY - 22103212210321

      References

      Reference overviewPub Med ID
      Neurotransmitters in airway parasympathetic neurons altered by neurotrophin-3 and repeated allergen challenge.
      Pan, J; Rhode, HK; Undem, BJ; Myers, AC
      American journal of respiratory cell and molecular biology  43  452-7  2010

      Show Abstract
      19901346 19901346
      Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice.
      Ritchie E Brown,James T McKenna,Stuart Winston,Radhika Basheer,Yuchio Yanagawa,Mahesh M Thakkar,Robert W McCarley
      The European journal of neuroscience  27  2008

      Show Abstract Full Text Article
      18215233 18215233
      Nociceptive behavioral responses to chemical, thermal and mechanical stimulation after unilateral, intrastriatal administration of 6-hydroxydopamine.
      Chudler, EH; Lu, Y
      Brain research  1213  41-7  2008

      Show Abstract
      18456244 18456244
      Effect of anti-NGF on ovarian expression of alpha1- and beta2-adrenoceptors, TrkA, p75NTR, and tyrosine hydroxylase in rats with steroid-induced polycystic ovaries.
      Manni, L; Holmäng, A; Cajander, S; Lundeberg, T; Aloe, L; Stener-Victorin, E
      American journal of physiology. Regulatory, integrative and comparative physiology  290  R826-35  2006

      Show Abstract
      16195501 16195501
      Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries.
      Luigi Manni, Agneta Holmäng, Thomas Lundeberg, Luigi Aloe, Elisabet Stener-Victorin, Luigi Manni, Agneta Holmäng, Thomas Lundeberg, Luigi Aloe, Elisabet Stener-Victorin
      Autonomic neuroscience : basic clinical  118  79-87  2005

      Show Abstract
      15795180 15795180
      Antibodies to a segment of tyrosine hydroxylase phosphorylated at serine 40.
      Goldstein, M, et al.
      J. Neurochem., 64: 2281-7 (1995)  1995

      Show Abstract
      7722513 7722513
      Antibodies to a synthetic peptide corresponding to a Ser-40-containing segment of tyrosine hydroxylase: activation and immunohistochemical localization of tyrosine hydroxylase.
      Lee, K Y, et al.
      J. Neurochem., 53: 1238-44 (1989)  1989

      Show Abstract
      2570128 2570128

      Data Sheet

      Title
      RABBIT ANTI-TYROSINE HYDROXYLASE POLYCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies