MABN1725 Anti-Thyroid Hormone Receptor β-1 Antibody, clone N402/46

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MABN1725
100 μg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, H, M IH(P), WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABN1725
      DescriptionAnti-Thyroid Hormone Receptor β-1 Antibody, clone N402/46
      Alternate Names
      • Thyroid hormone receptor beta
      • Nuclear receptor subfamily 1 group A member 2
      • c-erbA-2
      • c-erbA-beta
      Background InformationThyroid hormone receptor beta (UniProt: P10828; also known as Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta) is encoded by the THRB (also known as ERBA2, NR1A2, THR1) gene (Gene ID: 7068) in human. Thyroid hormone receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. Thyroid hormone receptor beta is a nuclear hormone receptor that has a transactivation domain at its N-terminal, a ligand-binding domain at the C-terminal, and a DNA-binding domain that binds to sequences of promoter DNA known as hormone response elements. It serves as a high affinity receptor for thyroid hormones, including triiodothyronine (T3) and thyroxine and serves as a hormone-dependent transcriptional regulator that binds DNA sequences and is activated by T3. It plays an important role in vertebrate development, specifically in developing limbs and face. 9-cis-retinoic acid receptor (RXR) and retinoic acid receptor (RAR) receptor families are often associated with thyroid hormone receptor -1 and form homodimers and heterodimers. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Thyroid Hormone Receptor -1, clone N402/46 Antibody, Cat. No. MABN1725, is a highly specific mouse monoclonal antibody that targets Thyroid Hormone Receptor -1 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Thyroid Hormone Receptor -1 in human pancreas and human liver tissue.

      Western Blotting Analysis: A representative lot detected Thyroid Hormone Receptor beta-1 in COS cells transiently transfected with Myc-tagged TRalpha1, Myc-tagged TRbeta1, Myc-tagged TRbeta2 or untagged Kv2.1 plasmid. (Courtesy of James Trimmer, Ph.D., University of California at Davis, USA).
      Biological Information
      ImmunogenA full-length human recombinant Thyroid Hormone Receptor beta-1.
      CloneN402/46
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone N402/46 detects Thyroid Hormone Receptor beta-1 in multiple human tissues.
      IsotypeIgG1κ
      Species Reactivity
      • Rat
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse, Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • THRB
      • ERBA2
      • NR1A2
      • THR1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~60 kDa observed; 52.79 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human cerebellum tissue.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Thyroid Hormone Receptor -1 in human cerebellum tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications