582005 | Anti-Telomerase (Ab-2) Rabbit pAb

582005
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H, M Rb Polyclonal Antibody

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      582005-100UL
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 100 ul
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          Description
          OverviewRecognizes the ~125 kDa telomerase (TERT) protein.
          Catalogue Number582005
          Brand Family Calbiochem®
          SynonymsAnti-TERT
          References
          ReferencesFu, W., et al. 2000. J. Mol. Neurosci. 14, 3.
          Kharbanda, S., et al. 2000. Curr. Biol. 10, 568.
          Vaziri, H., et al. 1999. Mol. Cell. Biol. 19, 2373.
          Product Information
          FormLiquid
          FormulationUndiluted serum.
          PreservativeNone
          Applications
          Key Applications Frozen Sections
          Immunoblotting (Western Blotting)
          Immunoprecipitation
          Paraffin Sections
          Application NotesFrozen Sections (1:250-1:1000)
          Immunoblotting (1:100)
          Immunprecipitation (1:40)
          Paraffin Sections (1:250-1:1000)
          Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
          Biological Information
          Immunogena synthetic peptide corresponding to amino acids from an internal region of the catalytic subunit of human telomerase reverse transcriptase (hTERT)
          ImmunogenHuman
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • Human
          • Mouse
          Antibody TypePolyclonal Antibody
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          582005

          References

          Reference overview
          Fu, W., et al. 2000. J. Mol. Neurosci. 14, 3.
          Kharbanda, S., et al. 2000. Curr. Biol. 10, 568.
          Vaziri, H., et al. 1999. Mol. Cell. Biol. 19, 2373.

          Technical Info

          Title
          Telomere, Telomerase, and Cellular Senescence and Death
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-August-2007 RFH
          SynonymsAnti-TERT
          ApplicationFrozen Sections (1:250-1:1000)
          Immunoblotting (1:100)
          Immunprecipitation (1:40)
          Paraffin Sections (1:250-1:1000)
          DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~125 kDa telomerase (TERT) protein.
          BackgroundThe 3' ends of chromosomes are capped with telomere sequences (TTAGGG; 6-26 nucleotides in length) by ribonucleo-protein telomerase during DNA replication. Telomerase is an unusual RNA-dependent DNA polymerase that uses an RNA component to specify the addition of telomere. In ciliated protozoa and yeast, telomere length is maintained by regulating the activity of telomerase. Many mammalian cells do not express telomerase, resulting into shortening of the telomere with each cell division, ultimately causing chromosomal instability, aging and cell death. ~4.8 kb of telomeric DNA is lost with each cell division. Most recently, introduction of telomerase into normal human cells has been shown to extend normal cell life by ~20 doublings.
          HostRabbit
          Immunogen speciesHuman
          Immunogena synthetic peptide corresponding to amino acids from an internal region of the catalytic subunit of human telomerase reverse transcriptase (hTERT)
          IsotypeIgG
          Specieshuman, mouse
          FormLiquid
          FormulationUndiluted serum.
          PreservativeNone
          CommentsVariables associated with assay conditions will dictate the optimal working dilution.
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesFu, W., et al. 2000. J. Mol. Neurosci. 14, 3.
          Kharbanda, S., et al. 2000. Curr. Biol. 10, 568.
          Vaziri, H., et al. 1999. Mol. Cell. Biol. 19, 2373.