ABE487 Anti-THRAP3 Antibody

View Products on Sigmaaldrich.com
ABE487
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IP, ICC, WB Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberABE487
      DescriptionAnti-THRAP3 Antibody
      Alternate Names
      • Thyroid hormone receptor-associated protein 3
      • Thyroid hormone receptor-associated protein complex 150 kDa component
      • Trap150
      Background InformationThyroid hormone receptor-associated protein 3 (THRAP3) is also called Thyroid hormone receptor-associated protein complex 150 kDa component (Trap150). THRAP3 plays a role in pre-mRNA splicing and is possibly involved in nuclear mRNA decay. THRAP3 regulates signal-induced alternative splicing, cyclin-D1/CCND1 mRNA stability and response to DNA damage. THRP3 is ubiquitously expressed across tissues.
      References
      Product Information
      FormatPurified
      Control
      • U2OS cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Thyroid hormone receptor-associated protein 3 using this rabbit polyclonal antibody, Anti-THRAP3 Antibody validated for use in IP, ICC & western blotting.
      Key Applications
      • Immunoprecipitation
      • Immunocytochemistry
      • Western Blotting
      Application NotesImmunoprecipitation Analysis: A representative lot immunoprecipitated THRAP3 in U20S cell lysates (Beli, P., et al. (2012). Mol Cell. 46(2):212-215).
      Immunocytochemistry Analysis: A representative lot detected THRAP3 in U20S cells (Bracken, C. P., et al. (2008). Cancer Res. 68(18):7621-7628).
      Western Blotting Analysis: A representative lot detected THRAP3 in untreated, and etoposide treated, hydroxyurea treated, 4NQO treated, and irradiated U20S cell lysates (Beli, P., et al. (2012). Mol Cell. 46(2):212-215).
      Western Blotting Analysis: A representative lot detected THRAP3 in U20S and THRAP3 transfected HEK293 cell lysates (Bracken, C. P., et al. (2008). Cancer Res. 68(18):7621-7628.).
      Biological Information
      ImmunogenRecombinant protein corresponding to human THRAP3.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • THRAP3
      • TRAP150
      Purification MethodProtein A/G
      UniProt Number
      Molecular Weight~150 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in U2OS cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected THRAP3 in 10 µg of U2OS cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-THRAP3 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-THRAP3 Antibody Certificates of Analysis

      TitleLot Number
      Anti-THRAP3 - Q2218166Q2218166

      References

      Reference overviewPub Med ID
      Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
      Beli, Petra, et al.
      Mol. Cell, 46: 212-25 (2012)  2012

      Show Abstract
      22424773 22424773
      Regulation of cyclin D1 RNA stability by SNIP1.
      Bracken, Cameron P, et al.
      Cancer Res., 68: 7621-8 (2008)  2008

      Show Abstract
      18794151 18794151