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AB9272 Anti-Synaptophysin Antibody

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AB9272
500 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB9272
      Replaces04-1019
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Synaptophysin Antibody
      References
      Product Information
      FormatAffinity Purified
      Control
      • POSITIVE CONTROL: Pancreas or Pheochromocytoma
      PresentationAffinity purified immunoglobulin. Liquid in 10 mM PBS, pH 7.4 containing BSA and 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Synaptophysin Antibody detects level of Synaptophysin & has been published & validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern blot

      Immunohistochemistry on formalin fixed, paraffin embedded tissue: 1:300 for 10 minutes at room temperature. Staining of formalin-fixed tissues requires boiling of tissues in 10 mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes.

      Optimal working dilutions must be determined by the end user.

      STAINING PATTERN: Cytoplasmic
      Biological Information
      ImmunogenSynthetic peptide from human synaptophysin.
      HostRabbit
      SpecificitySynaptophysin
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarySynaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.[supplied by OMIM]
      Gene Symbol
      • SYP
      • synaptophysin
      • Synaptophysin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08247 # Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.
      SIZE: 313 amino acids; 33845 Da
      SUBUNIT: Homohexamer or homotetramer.
      SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
      DOMAIN: SwissProt: P08247 The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
      PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity).
      SIMILARITY: Belongs to the synaptophysin/synaptobrevin family. & Contains 1 MARVEL domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C for up to 6 months after date of receipt.
      Packaging Information
      Material Size500 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Synaptophysin Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Synaptophysin Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-SYNAPTOPHYSIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2032210 2032210
      RABBIT ANTI-SYNAPTOPHYSIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2118903 2118903
      RABBIT ANTI-SYNAPTOPHYSIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2135088 2135088
      RABBIT ANTI-SYNAPTOPHYSIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2424088 2424088
      RABBIT ANTI-SYNAPTOPHYSIN - 3179221 3179221
      RABBIT ANTI-SYNAPTOPHYSIN - 3204898 3204898
      RABBIT ANTI-SYNAPTOPHYSIN - 3281626 3281626
      RABBIT ANTI-SYNAPTOPHYSIN - 3378760 3378760
      RABBIT ANTI-SYNAPTOPHYSIN - 3439801 3439801
      RABBIT ANTI-SYNAPTOPHYSIN - 3680736 3680736

      References

      Reference overviewApplicationSpeciesPub Med ID
      Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.
      Eggers, SD; Horn, AK; Roeber, S; Härtig, W; Nair, G; Reich, DS; Leigh, RJ
      PloS one  10  e0132075  2015

      Show Abstract
      26135580 26135580
      Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease.
      Fowler, SW; Chiang, AC; Savjani, RR; Larson, ME; Sherman, MA; Schuler, DR; Cirrito, JR; Lesné, SE; Jankowsky, JL
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  7871-85  2014

      Show Abstract
      Western Blotting24899710 24899710
      Active and passive immunization strategies based on the SDPM1 peptide demonstrate pre-clinical efficacy in the APPswePSEN1dE9 mouse model for Alzheimer's disease.
      Camboni, M; Wang, CM; Miranda, C; Yoon, JH; Xu, R; Zygmunt, D; Kaspar, BK; Martin, PT
      Neurobiology of disease  62  31-43  2014

      Show Abstract
      Western BlottingMouse24021662 24021662
      The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.
      Kandalepas, PC; Sadleir, KR; Eimer, WA; Zhao, J; Nicholson, DA; Vassar, R
      Acta neuropathologica  126  329-52  2013

      Show Abstract
      23820808 23820808
      GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses.
      Fiorentino, H; Kuczewski, N; Diabira, D; Ferrand, N; Pangalos, MN; Porcher, C; Gaiarsa, JL
      The Journal of neuroscience : the official journal of the Society for Neuroscience  29  11650-61  2009

      Show Abstract
      19759312 19759312

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)

      Data Sheet

      Title
      RABBIT ANTI-SYNAPTOPHYSIN AFFINITY PURIFIED POLYCLONAL ANTIBODY

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies