AB5060 Anti-Substance P Receptor Antibody, pain

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AB5060
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Gp, M, R IF, IHC, WB Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB5060
      ReplacesAB5800
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Substance P Receptor Antibody, pain
      Alternate Names
      • NK-1 Receptor
      Background InformationSubstance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
      References
      Product Information
      FormatSerum
      Control
      • Spinal Cord, brain membrane lysate
      PresentationRabbit polyclonal serum containing no preservative.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.
      Key Applications
      • Immunofluorescence
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry:
      A previous lot was used at 1:100-1:1,000 dilution.

      Western Blot Analysis:
      A previous lot was used at 1:500 dilution.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1).
      EpitopeC terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificitySpecific for the Substance P Receptor (NK-1).
      Species Reactivity
      • Guinea Pig
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • TAC1
      • NK2
      • NKA
      • NKNA
      • Hs.2563
      • PPT
      • TAC2
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20366 # Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
      SIZE: 129 amino acids; 15003 Da
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: P20366 ## Belongs to the tachykinin family.
      Molecular Weight35 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by western blot on Mouse brain membrane lysates.

      Western Blot Analysis:
      1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20ºC from date of receipt.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Substance P Receptor Antibody, pain SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Substance P Receptor Antibody, pain Certificates of Analysis

      TitleLot Number
      Anti-Substance P Receptor, pain - 21350682135068
      Anti-Substance P Receptor, pain - 24284932428493
      Anti-Substance P Receptor, pain - 24589922458992
      Anti-Substance P Receptor, pain - 20263702026370
      Anti-Substance P Receptor, pain - 20578202057820
      Anti-Substance P Receptor, pain - 22341182234118
      Anti-Substance P Receptor, pain - 23262992326299
      Anti-Substance P Receptor, pain - 25063152506315
      Anti-Substance P Receptor, pain - 31699283169928
      Anti-Substance P Receptor, pain - 34646043464604

      References

      Reference overviewApplicationSpeciesPub Med ID
      Large intercalated neurons of amygdala relay noxious sensory information.
      Bienvenu, TC; Busti, D; Micklem, BR; Mansouri, M; Magill, PJ; Ferraguti, F; Capogna, M
      The Journal of neuroscience : the official journal of the Society for Neuroscience  35  2044-57  2015

      Show Abstract
      25653362 25653362
      Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission.
      Zhao, ZQ; Wan, L; Liu, XY; Huo, FQ; Li, H; Barry, DM; Krieger, S; Kim, S; Liu, ZC; Xu, J; Rogers, BE; Li, YQ; Chen, ZF
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  12402-14  2014

      Show Abstract
      25209280 25209280
      Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification.
      Niedermair, T; Kuhn, V; Doranehgard, F; Stange, R; Wieskötter, B; Beckmann, J; Salmen, P; Springorum, HR; Straub, RH; Zimmer, A; Grifka, J; Grässel, S
      Matrix biology : journal of the International Society for Matrix Biology  38  22-35  2014

      Show Abstract
      Immunofluorescence25063231 25063231
      Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression.
      M Roche,D M Kerr,S P Hunt,J P Kelly
      Behavioural brain research  228  2012

      Show Abstract
      22155476 22155476
      Tachykinins stimulate a subset of mouse taste cells.
      Grant, J
      PloS one  7  e31697  2012

      Show Abstract
      22363709 22363709
      Terminal field and firing selectivity of cholecystokinin-expressing interneurons in the hippocampal CA3 area.
      Lasztóczi, B; Tukker, JJ; Somogyi, P; Klausberger, T
      The Journal of neuroscience : the official journal of the Society for Neuroscience  31  18073-93  2011

      Show Abstract
      Western Blotting22159120 22159120
      Different fear states engage distinct networks within the intercalated cell clusters of the amygdala.
      Busti, D; Geracitano, R; Whittle, N; Dalezios, Y; Mańko, M; Kaufmann, W; Sätzler, K; Singewald, N; Capogna, M; Ferraguti, F
      The Journal of neuroscience : the official journal of the Society for Neuroscience  31  5131-44  2011

      Show Abstract
      21451049 21451049
      Synaptic connections of calbindin-immunoreactive cone bipolar cells in the inner plexiform layer of rabbit retina.
      Shin Ae Kim,Choong Ki Jung,Tae-Hoon Kang,Ji Hyun Jeon,Jiook Cha,In-Beom Kim,Myung-Hoon Chun
      Cell and tissue research  339  2010

      Show Abstract
      19937346 19937346
      Phenotypic diversity and expression of GABAergic inhibitory interneurons during postnatal development in lumbar spinal cord of glutamic acid decarboxylase 67-green fluorescent protein mice.
      Dougherty, KJ; Sawchuk, MA; Hochman, S
      Neuroscience  163  909-19  2009

      Show Abstract Full Text Article
      19560523 19560523
      Spinal substance P and neurokinin-1 increase with high repetition reaching.
      Melanie B Elliott,Ann E Barr,Mary F Barbe
      Neuroscience letters  454  2009

      Show Abstract
      19429049 19429049

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies