MAB356 Anti-Substance P Antibody, pain, clone NC1

View Products on Sigmaaldrich.com
MAB356
100 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Ma IHC R Culture Supernatant Monoclonal Antibody
      Description
      Catalogue NumberMAB356
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Substance P Antibody, pain, clone NC1
      References
      Product Information
      FormatCulture Supernatant
      Control
      • Spinal Cord
      PresentationTissue culture supernatant. Liquid containing 1 mg/mL thimerosal.
      Quality LevelMQ100
      Applications
      ApplicationDetect Substance P using this Anti-Substance P Antibody, pain, clone NC1 validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application Notes1:100 - 1:200 by immunohistochemistry on human brain.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSubstance P conjugated to BSA.
      CloneNC1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityReacts with COOH-terminal end of Substance P. No cross-reactivity to Leu- or Met- enkephalin, somatostatin or beta-endorphin. Eledoisin 5%.
      IsotypeIgG2a
      Species Reactivity
      • Human
      • Mammals
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • TAC1
      • NKNA
      • Hs.2563
      • NK2
      • PPT
      • NKA
      • TAC2
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20366 # Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
      SIZE: 129 amino acids; 15003 Da
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: P20366 ## Belongs to the tachykinin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Substance P Antibody, pain, clone NC1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Substance P Antibody, pain, clone NC1 Certificates of Analysis

      TitleLot Number
      RAT ANTI-SUBSTANCE P MONOCLONAL ANTIBODY - 23909792390979
      RAT ANTI-SUBSTANCE P MONOCLONAL ANTIBODY - 24440742444074
      RAT ANTI-SUBSTANCE P - 25620922562092
      RAT ANTI-SUBSTANCE P - 31860923186092
      RAT ANTI-SUBSTANCE P - 32262893226289
      RAT ANTI-SUBSTANCE P - 33799363379936
      RAT ANTI-SUBSTANCE P - 34635823463582
      RAT ANTI-SUBSTANCE P -25490292549029
      RAT ANTI-SUBSTANCE P -25757562575756
      RAT ANTI-SUBSTANCE P -26048152604815

      References

      Reference overviewApplicationSpeciesPub Med ID
      Neurochemical features of endomorphin-2-containing neurons in the submucosal plexus of the rat colon.
      Li, JP; Zhang, T; Gao, CJ; Kou, ZZ; Jiao, XW; Zhang, LX; Wu, ZY; He, ZY; Li, YQ
      World journal of gastroenterology  21  9936-44  2015

      Show Abstract
      26379398 26379398
      Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine.
      Wang, GD; Wang, XY; Liu, S; Qu, M; Xia, Y; Needleman, BJ; Mikami, DJ; Wood, JD
      American journal of physiology. Gastrointestinal and liver physiology  307  G719-31  2014

      Show Abstract
      Immunohistochemistry25147231 25147231
      Expression of mu opioid receptor in dorsal diencephalic conduction system: new insights for the medial habenula.
      Gardon, O; Faget, L; Chu Sin Chung, P; Matifas, A; Massotte, D; Kieffer, BL
      Neuroscience  277  595-609  2014

      Show Abstract
      25086313 25086313
      Remote dose-dependent effects of dry needling at distant myofascial trigger spots of rabbit skeletal muscles on reduction of substance P levels of proximal muscle and spinal cords.
      Hsieh, YL; Yang, CC; Liu, SY; Chou, LW; Hong, CZ
      BioMed research international  2014  982121  2014

      Show Abstract
      25276839 25276839
      Neurochemical phenotype and function of endomorphin 2-immunopositive neurons in the myenteric plexus of the rat colon.
      Li, JP; Wang, XY; Gao, CJ; Liao, YH; Qu, J; He, ZY; Zhang, T; Wang, GD; Li, YQ
      Frontiers in neuroanatomy  8  149  2014

      Show Abstract
      25565974 25565974
      Neurochemical properties of BDNF-containing neurons projecting to rostral ventromedial medulla in the ventrolateral periaqueductal gray.
      Yin, JB; Wu, HH; Dong, YL; Zhang, T; Wang, J; Zhang, Y; Wei, YY; Lu, YC; Wu, SX; Wang, W; Li, YQ
      Frontiers in neural circuits  8  137  2014

      Show Abstract
      25477786 25477786
      Mutation of Elfn1 in mice causes seizures and hyperactivity.
      Dolan, J; Mitchell, KJ
      PloS one  8  e80491  2013

      Show Abstract
      24312227 24312227
      GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons in the primate putamen.
      Gonzales, KK; Pare, JF; Wichmann, T; Smith, Y
      The Journal of comparative neurology  521  2502-22  2013

      Show Abstract
      23296794 23296794
      Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture.
      Ramalingam, S; Daughtridge, GW; Johnston, MJ; Gracz, AD; Magness, ST
      American journal of physiology. Gastrointestinal and liver physiology  302  G10-20  2012

      Show Abstract
      Immunohistochemistry21995959 21995959
      Platelet-derived growth factor receptor α-positive cells in the tunica muscularis of human colon.
      Masaaki Kurahashi,Yasuko Nakano,Grant W Hennig,Sean M Ward,Kenton M Sanders
      Journal of cellular and molecular medicine  16  2012

      Show Abstract
      22225616 22225616

      Related Products & Applications

      Related Products

      Catalog Number Description  
      AB1566 Anti-Substance P Antibody, pain Show Pricing & Availability
      AB5060 Anti-Substance P Receptor Antibody, pain Show Pricing & Availability
      AB962 Anti-Substance P Antibody, pain Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies