AB1566 Anti-Substance P Antibody, pain

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AB1566
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R IH(P), RIA Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB1566
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Substance P Antibody, pain
      Background InformationSubstance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapse. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
      References
      Product Information
      FormatSerum
      Control
      • Spinal Cord.
      PresentationRabbit polyclonal serum containing 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Substance P Antibody, pain is validated for use in IH(P), RIA for the detection of Substance P.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Radioimmunoassay
      Application NotesRIA:
      1:10,000 dilution from a previous lot was used in radioimmunioassay. 80% binding detects at least 5 pg/mL.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSubstance P
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificitySubstance P
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • TAC1
      • NKNA
      • Hs.2563
      • NK2
      • PPT
      • NKA
      • TAC2
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20366 # Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
      SIZE: 129 amino acids; 15003 Da
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: P20366 ## Belongs to the tachykinin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunohistochemistry(paraffin):
      Substance P (AB1566) representative staining pattern/morphology in Alzheimer’s brain. Tissue pretreated with Citrate pH6.0, antigen retrieval. Antibody diluted to 1:100.
      IHC-Paraffin Staining With Citrate pH 6.0 Epitope Retrieval: Alzheimer’s Brain.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20ºC from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Substance P Antibody, pain SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Substance P Antibody, pain Certificates of Analysis

      TitleLot Number
      Anti-Substance P, pain - 23922272392227
      Anti-Substance P, pain - 24651192465119
      Anti-Substance P, pain - 22193302219330
      Anti-Substance P, pain - 22808292280829
      Anti-Substance P, pain - 30160143016014
      Anti-Substance P, pain - 3016014A3016014A
      Anti-Substance P, pain - 33942313394231
      Anti-Substance P, pain - JBC1774739JBC1774739
      Anti-Substance P, pain - JC1673160JC1673160
      Anti-Substance P, pain - LV1458672LV1458672

      References

      Reference overviewApplicationPub Med ID
      Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury.
      Fisher, PW; Zhao, Y; Rico, MC; Massicotte, VS; Wade, CK; Litvin, J; Bove, GM; Popoff, SN; Barbe, MF
      Journal of cell communication and signaling  9  37-54  2015

      Show Abstract
      25617052 25617052
      Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks.
      Michaelides, M; Anderson, SA; Ananth, M; Smirnov, D; Thanos, PK; Neumaier, JF; Wang, GJ; Volkow, ND; Hurd, YL
      The Journal of clinical investigation  123  5342-50  2013

      Show Abstract
      24231358 24231358
      Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models.
      Horne, EA; Coy, J; Swinney, K; Fung, S; Cherry, AE; Marrs, WR; Naydenov, AV; Lin, YH; Sun, X; Keene, CD; Grouzmann, E; Muchowski, P; Bates, GP; Mackie, K; Stella, N
      The European journal of neuroscience  37  429-40  2013

      Show Abstract
      23167744 23167744
      The interaction of force and repetition on musculoskeletal and neural tissue responses and sensorimotor behavior in a rat model of work-related musculoskeletal disorders.
      Barbe, MF; Gallagher, S; Massicotte, VS; Tytell, M; Popoff, SN; Barr-Gillespie, AE
      BMC musculoskeletal disorders  14  303  2013

      Show Abstract
      24156755 24156755
      Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury.
      Melanie B Elliott,Michael L Oshinsky,Peter S Amenta,Olatilewa O Awe,Jack I Jallo
      Headache  52  2012

      Show Abstract
      22568499 22568499
      Nerve growth factor derived from bronchial epithelium after chronic mite antigen exposure contributes to airway hyperresponsiveness by inducing hyperinnervation, and is inhibited by in vivo siRNA.
      H Ogawa,M Azuma,H Uehara,T Takahashi,Y Nishioka,S Sone,K Izumi
      Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology  42  2012

      Show Abstract
      22168511 22168511
      VEGF induces sensory and motor peripheral plasticity, alters bladder function, and promotes visceral sensitivity.
      Malykhina, AP; Lei, Q; Erickson, CS; Epstein, ML; Saban, MR; Davis, CA; Saban, R
      BMC physiology  12  15  2012

      Show Abstract
      23249422 23249422
      Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a model of traumatic brain injury.
      Elliott MB, Tuma RF, Amenta PS, Barbe MF, Jallo JI.
      Journal of neurotrauma  28  973-81  2011

      Show Abstract
      21332427 21332427
      Three days after a single exposure to ozone, the mechanism of airway hyperreactivity is dependent on substance P and nerve growth factor.
      Verhein, KC; Hazari, MS; Moulton, BC; Jacoby, IW; Jacoby, DB; Fryer, AD
      American journal of physiology. Lung cellular and molecular physiology  300  L176-84  2011

      Show Abstract
      21056958 21056958
      Morphological changes in the enteric nervous system of aging and APP23 transgenic mice.
      Van Ginneken C, Schäfer KH, Van Dam D, Huygelen V, De Deyn PP
      Brain Res  1378  43-53. Epub 2011 Jan 15.  2011

      Show Abstract
      21241669 21241669

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies