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AB5776 Anti-Sox11 Antibody, pain

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AB5776
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5776
      ReplacesAB9090
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Sox11 Antibody, pain
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Precipitated antibody in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Sox11 Antibody, pain is an antibody against Sox11 for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern blot: 1:200-1:1,000 using ECL.

      Immunohistochemistry: 1:200-1:1,000.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide, amino acids 115-131 from human Sox-11.
      HostRabbit
      SpecificityRecognizes Sox-11, a high mobility group (HMG) transcription factor.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.
      Gene Symbol
      • SOX11
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P35716 # Probably important in the developing nervous system.
      SIZE: 441 amino acids; 46679 Da
      SUBCELLULAR LOCATION: Nucleus (Potential).
      TISSUE SPECIFICITY: Expressed mainly in the nervous system.
      SIMILARITY: SwissProt: P35716 ## Contains 1 HMG box DNA-binding domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain unopened vial at -70°C for up to 6 months. Avoid repeated freeze/thaw cycles.

      PREPARATION AND USE:

      To reconstitute the antibody, centrifuge the antibody vial at moderate speed (5,000 rpm) for 5 minutes to pellet the precipitated antibody product. Carefully remove the ammonium sulfate/PBS buffer solution and discard. It is not necessary to remove all of the ammonium sulfate/PBS solution: 10 μL of residual ammonium sulfate solution will not affect the resuspension of the antibody. Do not let the protein pellet dry, as severe loss of antibody reactivity can occur.

      Resuspend the antibody pellet in a suitable biological buffer such as PBS or TBS (pH 7.3-7.5) to a final concentration of 1.0 mg/mL. For example, to achieve a 1.0 mg/mL concentration with 50 μg of precipitated antibody, the amount of buffer needed would be 50 μL.

      Carefully add the liquid buffer to the pellet. DO NOT VORTEX. Mix by gentle stirring with a wide pipet tip or gentle finger-tapping. Let the precipitated antibody rehydrate for 1 hour at 4-25°C prior to use. Small particles of precipitated antibody that fail to resuspend are normal. Vials are overfilled to compensate for any losses.

      The rehydrated antibody solutions can be stored undiluted at 2-8°C for 2 months without any significant loss of activity. Note, the solution is not sterile, thus care should be taken if product is stored at 2-8°C.

      For storage at -20°C, the addition of an equal volume of glycerol can be used, however, it is recommended that ACS grade or higher glycerol be used, as significant loss of activity can occur if the glycerol used is not of high quality.

      For long-term storage at -70°C, it is recommended that the rehydrated antibody solution be further diluted 1:1 with a 2% BSA (fraction V, highest-grade available) solution made with the rehydration buffer. The resulting 1% BSA/antibody solution can be aliquoted and stored frozen at -70°C for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Sox11 Antibody, pain SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Sox11 Antibody, pain Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-Sox-11 - 3378623 3378623
      RABBIT ANTI-Sox-11 -2817260 2817260
      RABBIT ANTI-Sox-11 AFFINITY PURIFIED POLYCLONAL ANTIBODY 3054693
      RABBIT ANTI-Sox-11 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2068430 2068430
      RABBIT ANTI-Sox-11 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2274250 2274250

      References

      Reference overviewPub Med ID
      Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis.
      Anja Haslinger,Tobias J Schwarz,Marcela Covic,D Chichung Lie,D Chichung Lie
      The European journal of neuroscience  29  2009

      Show Abstract
      19490090 19490090

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies