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ABN105 Anti-Sox11 Antibody

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ABN105
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, Immunohistochemistry (Tissue)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN105
      DescriptionAnti-Sox11 Antibody
      Alternate Names
      • Transcription factor SOX-11
      Background InformationSRY box-containing 11 (Sox11) is a neural transcription factor belonging to the DNA-binding high-mobility group (HMG) box protein super family. It is highly expressed during embryonic development and regulates genes involved in neurite growth and survival. Sox11 plays an important role in the formation of sensory neurons and organogenesis. Sox11-deficient mice show defects in multiple organs including the lung, heart, and pancreas. Sox11 also plays a critical role as a tumor suppressor. Epigenetic suppression of the Sox11 gene, primarily through promoter hypermethylation, contributes to various forms of neoplasms. In adults, Sox11 may be involved in the regeneration of neurons after nerve injury by inducing the expression of the small proline rich protein 1a gene (Sprr1a).
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse brain tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Sox11 Antibody detects level of Sox11 & has been published & validated for use in 0.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Tissue)
      Application NotesImmunohistochemistry: A 1:1,000 dilution from a representative lot detected Sox-11 in normal mouse hippocampus and cerebellum tissues.

      Western Blot Analysis: A representative lot detecte Sox-11 in human brain tissue lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Sox-11.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SOX11
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~57 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse brain tissue lysate.

      Western Blot Analysis: 0.5 mg/mL of this antibody detected Sox-11 in 10 mg of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies