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AB5681-I Anti-Somatostatin Receptor Type 5 Antibody

AB5681-I
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5681-I
      ReplacesAB5681
      DescriptionAnti-Somatostatin Receptor Type 5 Antibody
      Alternate Names
      • Somatostatin receptor type 5
      • SS-5-R
      • SS5-R
      • SS5R
      Background InformationSomatostatin receptor type 5 (UniProt P35346; also known as SS-5-R, SS5-R, SS5R) is encoded by the SSTR5 gene (Gene ID 6755) in human. Somatostatin receptor type 5 is an inhibitory G-protein coupled receptor (GPCR) which regulates hormone secretion in the pituitary and in pancreatic islets. SSTR5 uses its PDZ ligand motif to interact with PSD-95/discs large/ZO-1 (PDZ) domain proteins, such as the Golgi-associated protein PIST (also termed GOPC, CAL or FIG), endosomal sorting nexin 27 (SNX27), and the scaffold proteins NHERF-1 & NHERF-3 (PDZ-K1). SNX27 is reported to stabilize SSTR5 by preventing its lysosomal degradation, while NHERF-1 & NHERF-3 mediate SSTR5 plasma membrane localizatin and enable its coupling to signaling partners, such as phospholipase C-β3. PIST stabilizes SSTR5 association with the trans-Golgi network (TGN) before it is recruited to the plasma membrane by NHERF proteins.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Somatostatin Receptor Type 5 Antibody is validated for use in Western Blotting, Immunohistochemistry for the detection of Somatostatin Receptor Type 5 .
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Somatostatin Receptor Type 5 in mouse brain, human small intestine, and rat heart tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a sequence from the C-terminal cytoplasmic domain of human Somatostatin receptor type 5.
      EpitopeC-terminal cytoplasmic domain
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificitySomatostatin Receptor 5 (SSTR5). The antibody reacts with both natural and recombinant protein. Epitope location is cytoplasmic.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SSTR5
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~55 kDa observed. Target band size appears larger than the calculated molecular weight of 39.2 kDa due to glycosylation.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MCF-7 cell lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected Somatostatin Receptor Type 5 in 10 µg of MCF-7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies