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MABN130 Anti-SQSTM1 Antibody, clone 20F1.1

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MABN130
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN130
      DescriptionAnti-SQSTM1 Antibody, clone 20F1.1
      Alternate Names
      • Sequestosome-1
      • EBI3-associated protein of 60 kDa
      • EBIAP
      • p60
      • Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
      • Ubiquitin-binding protein p62
      Background InformationUbiquitin-binding protein p62, also known as Sequestosome-1 (SQSTM1), is a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-κB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-κB in response to upstream signals. Defects in p62/SQSTM1 are a cause of Paget disease of bone (PDB), a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts
      References
      Product Information
      FormatPurified
      Control
      • Rat brain tissue lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SQSTM1 Antibody, clone 20F1.1 is a highly specific mouse monoclonal antibody, that targets p62 & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SQSTM1 in human thalamus and human cerebellum tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human SQSTM1.
      Clone20F1.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Rat
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SQSTM1
      • ORCA
      • OSIL
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~60 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected SQSTM1 in 10 µg of rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies