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MABC277 Anti-SOX9 Antibody, clone 10E4.1

MABC277
100 μg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIH(P), IPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC277
      DescriptionAnti-SOX9 Antibody, clone 10E4.1
      Alternate Names
      • Transcription factor SOX-9
      • Sex-determining region Y-box 9 protein
      • SRY-related HMG-box gene 9
      Background InformationTranscription factor SOX-9 (UniProt P48436; also known as Sex-determining region Y-box 9 protein, SRY-related HMG-box gene 9) is encoded by the SOX9 (also known as CMD1, CMPD1, SRA1) gene (Gene ID 6662) in human. Sox family of genes are related to the mammalian sex determining gene SRY. These genes contain sequences encoding for the HMG-box domains that mediate sequence-specific DNA binding. SOX genes encode transcriptional regulators involved in cell fate decision during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at at least 40 genomic loci and at least 30 Sox genes have been identified. SOX-9 is a key regulator of developmental processes, including male sex determination, chondrogenesis, neurogenesis, and neural crest development. SOX-9 up-regulation is reported in cancers of various origins, including breast, colon, prostate, and lung, where its expression correlates with malignancy and patient survival. Cellular SOX9 mRNA is shown to be targeted and negatively regulated by miR-32, and the cellular miR-32 level is reported to be significantly lower in non-small cell lung cancer (NSCLC) compared with noncancerous lung tissues.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SOX9 Antibody, clone 10E4.1 is an antibody against SOX9 for use in Immunohistochemistry (Paraffin), Immunoprecipitation.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated SOX9 from 500 µg of human chondrocyte lysate.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to a sequence from the N-terminal region of human SOX9.
      EpitopeN-terminal region.
      Clone10E4.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 10E4.1 recognizes an epitope in the N-terminal region of SOX-9.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SOX9
      • CMD1
      • CMPD1
      • SRA1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~65 kDa observed. 56.14 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in rat testis tissue.

      Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected SOX9 in rat testis tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies