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MAB4343 Anti-SOX-2 Antibody

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MAB4343
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MICC, IHC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB4343
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-SOX-2 Antibody
      Background InformationSox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.
      References
      Product Information
      FormatPurified
      PresentationPurified Immunoglobulin by protein A affinity chromatography and presented as a liquid in 0.02 M phosphate buffer, pH 7.6, with 0.25 M NaCl. Contains 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SOX-2 Antibody detects level of SOX-2 & has been published & validated for use in IC, IH & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Biological Information
      ImmunogenRecombinant GST Fusion protein.
      Clone6F1.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2b
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
      Gene Symbol
      • SOX2
      • ANOP3
      • MGC2413
      • MCOPS3
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P48431 # Can form ternary complexes with OCT-1 or OCT-3 but acts as a transcriptional activator of FGF-4 enhancer DNA sequences only in conjunction with OCT-3 (By similarity).
      SIZE: 317 amino acids; 34310 Da
      SUBCELLULAR LOCATION: Nucleus.
      DISEASE: SwissProt: P48431 # Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. MCOPS3 is characterized by the association of microphthalmia or clinical anophthalmia with anomalies such as microcephaly, short stature, hypogonadotropic hypogonadism, esophageal atresia and neurologic manifestations.
      SIMILARITY: SwissProt: P48431 ## Contains 1 HMG box DNA-binding domain.
      Stem Cell Type
      • Human Embryonic Stem Cells
      • Mouse Embryonic Stem Cells
      • Neural Stem Cells
      • Induced Pluripotent Stem Cells
      Molecular Weight~34 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-SOX-2 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-SOX-2 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Sox-2 (Mouse Monoclonal) MONOCLONAL ANTIBODY Q2922336
      MOUSE ANTI-SOX-2 MONOCLONAL ANTIBODY - 2373399 2373399
      MOUSE ANTI-SOX-2 MONOCLONAL ANTIBODY - 2462883 2462883
      MOUSE ANTI-SOX-2 MONOCLONAL ANTIBODY - 2168257 2168257
      MOUSE ANTI-SOX-2 - 3328979 3328979
      MOUSE ANTI-SOX-2 - 3454421 3454421
      MOUSE ANTI-SOX-2 - 3593167 3593167
      MOUSE ANTI-SOX-2 -2575897 2575897
      MOUSE ANTI-SOX-2 -2619399 2619399
      MOUSE ANTI-SOX-2 -2677790 2677790

      References

      Reference overviewApplicationSpeciesPub Med ID
      Genome-Wide Definition of Promoter and Enhancer Usage during Neural Induction of Human Embryonic Stem Cells.
      Poletti, V; Delli Carri, A; Malagoli Tagliazucchi, G; Faedo, A; Petiti, L; Mazza, EM; Peano, C; De Bellis, G; Bicciato, S; Miccio, A; Cattaneo, E; Mavilio, F
      PloS one  10  e0126590  2015

      Show Abstract
      25978676 25978676
      Upregulation of pluripotency markers in adipose tissue-derived stem cells by miR-302 and leukemia inhibitory factor.
      Taha, MF; Javeri, A; Rohban, S; Mowla, SJ
      BioMed research international  2014  941486  2014

      Show Abstract
      25147827 25147827
      IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L.
      Kryczek, I; Lin, Y; Nagarsheth, N; Peng, D; Zhao, L; Zhao, E; Vatan, L; Szeliga, W; Dou, Y; Owens, S; Zgodzinski, W; Majewski, M; Wallner, G; Fang, J; Huang, E; Zou, W
      Immunity  40  772-84  2014

      Show Abstract
      24816405 24816405
      Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features.
      Mastronuzzi, A; Miele, E; Po, A; Antonelli, M; Buttarelli, FR; Colafati, GS; del Bufalo, F; Faedda, R; Spinelli, GP; Carai, A; Giangaspero, F; Gulino, A; Locatelli, F; Ferretti, E
      BMC cancer  14  262  2014

      Show Abstract
      24739212 24739212
      Genome wide profiling of dopaminergic neurons derived from human embryonic and induced pluripotent stem cells.
      Momčilović, O; Liu, Q; Swistowski, A; Russo-Tait, T; Zhao, Y; Rao, MS; Zeng, X
      Stem cells and development  23  406-20  2014

      Show Abstract
      24074155 24074155
      Characterization of embryonic stem-like cells derived from HEK293T cells through miR302/367 expression and their potentiality to differentiate into germ-like cells.
      Wang, L; Zhu, H; Wu, J; Li, N; Hua, J
      Cytotechnology  66  729-40  2014

      Show Abstract
      24091881 24091881
      Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway.
      Li, H; Zhong, X; Chau, KF; Santistevan, NJ; Guo, W; Kong, G; Li, X; Kadakia, M; Masliah, J; Chi, J; Jin, P; Zhang, J; Zhao, X; Chang, Q
      Nature communications  5  5601  2014

      Show Abstract
      25420914 25420914
      Genetic reprogramming of human amniotic cells with episomal vectors: neural rosettes as sentinels in candidate selection for validation assays.
      Wilson, PG; Payne, T
      PeerJ  2  e668  2014

      Show Abstract
      25426336 25426336
      Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.
      Cui, TX; Kryczek, I; Zhao, L; Zhao, E; Kuick, R; Roh, MH; Vatan, L; Szeliga, W; Mao, Y; Thomas, DG; Kotarski, J; Tarkowski, R; Wicha, M; Cho, K; Giordano, T; Liu, R; Zou, W
      Immunity  39  611-21  2013

      Show Abstract
      24012420 24012420
      Characterization of induced neural progenitors from skin fibroblasts by a novel combination of defined factors.
      Tian, C; Liu, Q; Ma, K; Wang, Y; Chen, Q; Ambroz, R; Klinkebiel, DL; Li, Y; Huang, Y; Ding, J; Wu, J; Zheng, JC
      Scientific reports  3  1345  2013

      Show Abstract
      ImmunocytochemistryMouse23439431 23439431

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies