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AB10346 Anti-SOD2 Antibody

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AB10346
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10346
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-SOD2 Antibody
      Alternate Names
      • Superoxide Dismutase 2 (SOD2)
      Background InformationThis gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
      References
      Product Information
      FormatSerum
      PresentationRaw rabbit serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-SOD2 Antibody is validated for use in WB for the detection of SOD2.
      Key Applications
      • Western Blotting
      Application Notes Western Blot: 1:5000
      Biological Information
      ImmunogenRecombinant human SOD2
      EpitopeAA G93 – Y217
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
      Gene Symbol
      • EC 1.15.1.1
      • IPO-B
      • MNSOD
      • Mn-SOD
      • MnSOD
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04179#Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
      SIZE: 222 amino acids; 24722 Da
      SUBCELLULAR LOCATION: Mitochondrion matrix.
      SIMILARITY: SwissProt: P04179# Belongs to the iron/manganese superoxide dismutase family.
      Molecular Weight28 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for up to 12 months from date of receipt.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-SOD2 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-SOD2 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Superoxide Dismutase 2 (SOD2) 3078253
      Anti-Superoxide Dismutase 2 (SOD2) - 2040380 2040380
      Anti-Superoxide Dismutase 2 (SOD2) - 2492797 2492797
      Anti-Superoxide Dismutase 2 (SOD2) - AB10346 AB10346
      Anti-Superoxide Dismutase 2 (SOD2) -2608438 2608438
      Anti-Superoxide Dismutase 2 (SOD2) -2888835 2888835
      Anti-Superoxide Dismutase 2 (SOD2) Polyclonal Antibody 3087194
      Anti-Superoxide Dismutase 2 (SOD2) Polyclonal Antibody 2865459
      Anti-Superoxide Dismutase 2 (SOD2), Polyclonal Antibody 2840177

      References

      Reference overviewApplicationPub Med ID
      PGC-1α buffers ROS-mediated removal of mitochondria during myogenesis.
      Baldelli, S; Aquilano, K; Ciriolo, MR
      Cell death & disease  5  e1515  2014

      Show Abstract
      25375380 25375380
      Loss of LRPPRC causes ATP synthase deficiency.
      Mourier, A; Ruzzenente, B; Brandt, T; Kühlbrandt, W; Larsson, NG
      Human molecular genetics  23  2580-92  2014

      Show Abstract
      24399447 24399447
      Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes.
      Cyr, AR; Brown, KE; McCormick, ML; Coleman, MC; Case, AJ; Watts, GS; Futscher, BW; Spitz, DR; Domann, FE
      Redox biology  1  172-7  2013

      Show Abstract
      Immunohistochemistry24024150 24024150

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress (EMD)

      Technical Info

      Title
      White Paper- Modern Methods in Oxidative Stress Research (EMD)

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies