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ABC99 Anti-SFTPC Antibody

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ABC99
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC99
      DescriptionAnti-SFTPC Antibody
      Alternate Names
      • Pulmonary surfactant-associated protein C
      • SP-C
      • Pulmonary surfactant-associated proteolipid SPL(Val)
      • SP5
      Background InformationSFTPC, also known as SFTP2 and Pulmonary surfactant-associated protein C, is a complex mixture of phospholipids and proteins secreted from airway epithelial cells (type II cells) in alveoli which reduces the surface tension at the alveolar air liquid interface, providing alveolar stability necessary for normal ventilation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP A (28 - 36 kDa) and SP D (43 kDa) are collagenous carbohydrate binding proteins, whereas SP B (8 - 9 kDa) and SP C (4 kDa) are non collagenous hydrophobic proteins. SP C is a fragment of a much larger precursor protein of 21 kDa. The precursor contains an exceedingly hydrophobic region of 34 amino acids that comprises most of the mature SP C, and a unique poly-valine domain.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Rat lung tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect SP-C using this rabbit polyclonal antibody, Anti-SFTPC Antibody validated for use in western blotting & IHC (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected SFTPC in human lung tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the N-terminus of human SFTPC.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SFTPC
      • SFTP2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~20 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat lung tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected SFTPC in 10 µg of rat lung tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-SFTPC Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-SFTPC Antibody Certificates of Analysis

      TitleLot Number
      Anti-SFTPC - 3022853 3022853
      Anti-SFTPC - 3258756 3258756
      Anti-SFTPC - 3448589 3448589
      Anti-SFTPC - 3513651 3513651
      Anti-SFTPC - 3727144 3727144
      Anti-SFTPC - Q2231705 Q2231705
      Anti-SFTPC Polyclonal Antibody 2924636

      References

      Reference overviewPub Med ID
      Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma.
      Chen, Y; Terajima, M; Yang, Y; Sun, L; Ahn, YH; Pankova, D; Puperi, DS; Watanabe, T; Kim, MP; Blackmon, SH; Rodriguez, J; Liu, H; Behrens, C; Wistuba, II; Minelli, R; Scott, KL; Sanchez-Adams, J; Guilak, F; Pati, D; Thilaganathan, N; Burns, AR; Creighton, CJ; Martinez, ED; Zal, T; Grande-Allen, KJ; Yamauchi, M; Kurie, JM
      The Journal of clinical investigation  125  1147-62  2015

      Show Abstract
      25664850 25664850

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies