MAB5478 Anti-Retinoid X Receptor α Antibody

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MAB5478
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M ELISA, EMSA, IP, WB M Ascites Monoclonal Antibody
      Description
      Catalogue NumberMAB5478
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Retinoid X Receptor α Antibody
      Alternate Names
      • RXRalpha
      References
      Product Information
      FormatAscites
      PresentationAscites fluid. Liquid. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-Retinoid X Receptor α Antibody (Mouse Monoclonal Antibody) validated in ELISA, EMSA, IP, WB to detect Retinoid X Receptor α also known as RXR alpha.
      Key Applications
      • ELISA
      • Electrophoretic Mobility Shift Assay
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot (endogenous and recombinant protein): 1:500-1:5,000

      Immunocytochemistry (transfected cells): 1:500-1:5,000

      Immunoprecipitation (endogenous and recombinant protein): 1:500-1:5,000

      Gel shift (endogenous and recombinant protein): 1:500-1:5,000

      ELISA: 1:500-1:5,000

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenFusion protein corresponding to the DE-region of mouse RXRa.
      HostMouse
      SpecificityReacts with Retinoid X Receptor alpha (RXRalpha). No cross reactivity with RXRbeta or RXRgamma.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryRetinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.
      Gene Symbol
      • RXRA
      • FLJ16020
      • FLJ16733
      • NR2B1
      • MGC102720
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P19793 # Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer (By similarity).
      SIZE: 462 amino acids; 50811 Da
      SUBUNIT: Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma called adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (By similarity). Interacts with SFPQ. Interacts with HCV core protein. Interacts with PELP1. Interacts with SENP6.
      SUBCELLULAR LOCATION: Nucleus.
      TISSUE SPECIFICITY: Highly expressed in liver, also found in lung, kidney and heart.
      DOMAIN: SwissProt: P19793 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
      PTM: Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6.
      SIMILARITY: Belongs to the nuclear hormone receptor family. NR2 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Retinoid X Receptor α Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Retinoid X Receptor α Antibody Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-RETINOID X RECEPTOR α - 32138763213876
      MOUSE ANTI-RETINOID X RECEPTOR α MONOCLONAL ANTIBODY - 23956382395638
      MOUSE ANTI-RETINOID X RECEPTOR α MONOCLONAL ANTIBODY -27339362733936

      References

      Reference overviewPub Med ID
      Retinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.
      Coleman, DJ; Garcia, G; Hyter, S; Jang, HS; Chagani, S; Liang, X; Larue, L; Ganguli-Indra, G; Indra, AK
      PLoS genetics  10  e1004321  2014

      Show Abstract
      24810760 24810760
      Identification and characterization of the human NOL7 gene promoter.
      Mankame, TP; Zhou, G; Lingen, MW
      Gene  456  36-44  2010

      Show Abstract
      20206243 20206243