AB9482 Anti-Retinoid-Related Orphan Receptor β Antibody

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AB9482
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IH(P) Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB9482
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Retinoid-Related Orphan Receptor β Antibody
      Alternate Names
      • ROR Beta/NR
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-Retinoid-Related Orphan Receptor β Antibody (Rabbit Polyclonal Antibody) validated in IHC(P) to detect Retinoid-Related Orphan Receptor β also known as ROR Beta/NR.
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry on paraffin embedded tissue sections.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from the hinge domain of human Retinoid-Related Orphan Receptor Beta.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Retinoid-Related Orphan Receptor Beta [ROR Beta/NR].
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.
      Gene Symbol
      • RORB
      • ROR-BETA
      • NR1F2
      • RZRB
      • bA133M9.1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q92753 # Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter (By similarity).
      SIZE: 470 amino acids; 53220 Da
      SUBCELLULAR LOCATION: Nucleus (Probable).
      SIMILARITY: SwissProt: Q92753 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in Japan.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Retinoid-Related Orphan Receptor β Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Retinoid-Related Orphan Receptor β Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI- RETINOID-RELATED ORPHAN RECEPTOR BETA2466930
      RABBIT ANTI- RETINOID-RELATED ORPHAN RECEPTOR BETA - 32483913248391
      RABBIT ANTI- RETINOID-RELATED ORPHAN RECEPTOR BETA -25357672535767
      RABBIT ANTI- RETINOID-RELATED ORPHAN RECEPTOR BETA -25499702549970
      RABBIT ANTI- RETINOID-RELATED ORPHAN RECEPTOR BETA -25659212565921
      RABBIT ANTI- RETINOID-RELATED ORPHAN RECEPTOR BETA AFFINITY PURIFIED POLYCLONAL ANTIBODY -24854732485473

      References

      Reference overviewPub Med ID
      Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence.
      Gagrica, S; Brookes, S; Anderton, E; Rowe, J; Peters, G
      Cancer research  72  165-75  2012

      Show Abstract
      22080569 22080569
      Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart.
      Ricchiuti, V; Lapointe, N; Pojoga, L; Yao, T; Tran, L; Williams, GH; Adler, GK
      The Journal of endocrinology  211  47-54  2011

      Show Abstract
      21746791 21746791
      The pathogenic role of the canonical Wnt pathway in age-related macular degeneration.
      Zhou, T; Hu, Y; Chen, Y; Zhou, KK; Zhang, B; Gao, G; Ma, JX
      Investigative ophthalmology & visual science  51  4371-9  2010

      Show Abstract Full Text Article
      19875668 19875668
      Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice.
      Yi-Fan Chen, Cheng-Heng Kao, Ya-Ting Chen, Chih-Hao Wang, Chia-Yu Wu, Ching-Yen Tsai, Fu-Chin Liu, Chu-Wen Yang, Yau-Huei Wei, Ming-Ta Hsu, Shih-Feng Tsai, Ting-Fen Tsai, Yi-Fan Chen, Cheng-Heng Kao, Ya-Ting Chen, Chih-Hao Wang, Chia-Yu Wu, Ching-Yen Tsai, Fu-Chin Liu, Chu-Wen Yang, Yau-Huei Wei, Ming-Ta Hsu, Shih-Feng Tsai, Ting-Fen Tsai, Yi-Fan Chen, Cheng-Heng Kao, Ya-Ting Chen, Chih-Hao Wang, Chia-Yu Wu, Ching-Yen Tsai, Fu-Chin Liu, Chu-Wen Yang, Yau-Huei Wei, Ming-Ta Hsu, Shih-Feng Tsai, Ting-Fen Tsai
      Genes development  23  1183-94  2009

      Show Abstract Full Text Article
      19451219 19451219