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ABT179 Anti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody)

This Anti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody) is validated for use in Western Blotting and Immunohistochemistry for the detection of Pro-neuregulin-1, membrane-bound isoform (NRG1).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: NRG1, GGF, HGL, HRGA, NDF, SMDF UniProt Number: Q02297
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ABT179
100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABT179
      DescriptionAnti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody)
      Alternate Names
      • Pro-neuregulin-1, membrane-bound isoform
      • Pro-NRG1
      • Neuregulin-1
      • Acetylcholine receptor-inducing activity
      • ARIA
      • Breast cancer cell differentiation factor p45
      • Glial growth factor
      • Heregulin
      • HRG
      • Neu differentiation factor
      • Sensory and motor neuron-derived factor
      Background InformationNeuregulin isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9). Neuregulin Type I/II serve as direct ligands for ERBB3 and ERBB4 tyrosine kinase receptors that regulate development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Type I isoforms are the predominant forms expressed in the endocardium. Type II is the major form in skeletal muscle cells, and is expressed in the spinal cord, brain, adult heart, placenta, lung, liver, kidney, and pancreas. Neuregulin-HBD refers to the heparin binding domain of Type I/II Neuregulin.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody) is validated for use in Western Blotting and Immunohistochemistry for the detection of Pro-neuregulin-1, membrane-bound isoform (NRG1).
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Pro-neuregulin-1, membrane-bound isoform (NRG1) in human cardiac myocytes and human cerebellum tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the extracellular domain of human Pro-neuregulin-1, membrane-bound isoform (NRG1).
      EpitopeExtracellular domain
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis antibody is expected to cross-react to all Alpha and Beta isoforms (Alpha1A, Alpha2B, Alpha3; and Beta1/1A, Beta2, Beta3), also known as Type I.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Chimpanzee based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NRG1
      • GGF
      • HGL
      • HRGA
      • NDF
      • SMDF
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~110 and ~58 kDa observed. May detect multiple isoforms (Alpha1A, Alpha2B, Alpha3; and Beta1/1A, Beta2, Beta3).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC3 cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected Pro-neuregulin-1, membrane-bound isoform (NRG1) in 10 µg of PC3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABT179 04055977109269