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MABS37 Anti-Peroxiredoxin-4 Antibody, clone CPTC-PRDX4-3

MABS37
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS37
      DescriptionAnti-Peroxiredoxin-4 Antibody, clone CPTC-PRDX4-3
      Alternate Names
      • peroxiredoxin 4
      • thioredoxin peroxidase (antioxidant enzyme)
      • Antioxidant enzyme AOE372
      • Thioredoxin peroxidase AO372
      • peroxiredoxin-4
      • Peroxiredoxin IV
      • Thioredoxin-dependent peroxide reductase A0372
      Background InformationPeroxiredoxin-4 (PRDX4), sometimes referred to as antioxidant enzyme AOE372, is part of the thioredoxin peroxidase family of antioxidants. Antioxidants can reduce reactive oxygen species, such as hydrogen peroxide, and seem to regulate intracellular peroxide levels which have some control over signal transduction. Peroxiredoxin-4 uses the peroxide substrate to oxidize an active-site cysteine to a sulfenic acid.
      References
      Product Information
      FormatPurified
      Control
      • Human pancreas tissue lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Peroxiredoxin-4 Antibody, clone CPTC-PRDX4-3 is an antibody against Peroxiredoxin-4 for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenFull length recombinant protein corresponding to human Peroxiredoxin-4.

      Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
      CloneCPTC-PRDX4-3
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq].
      Gene Symbol
      • PRX-4
      • PRDX4
      • AOE37-2
      • prx-IV
      • Prx-IV
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.

      CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

      SUBUNIT STRUCTURE: Homodimer or heterodimer with PRDX1; disulfide-linked, upon oxidation (By similarity).

      SUBCELLULAR LOCATION: Cytoplasm. Secreted

      MISCELLANEOUS: The active site is the redox-active Cys-124 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-245-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.

      Irreversibly inactivated by overoxidation of Cys-124 (to Cys-SO3H) upon oxidative stress.

      SEQUENCE SIMILARITIES: Belongs to the ahpC/TSA family.

      Contains 1 thioredoxin domain.
      Molecular Weight ~ 26 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human pancreas tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Peroxiredoxin-4 on 10 µg of human pancreas tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Catalog Number Description  
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies