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07-612 Anti-Peroxiredoxin 4 Antibody

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07-612
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbSerumPolyclonal Antibody
      Description
      Catalogue Number07-612
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Peroxiredoxin 4 Antibody
      References
      Product Information
      FormatSerum
      Presentationantiserum with 0.05% sodium azide before the addition of glycerol to 30%
      Quality LevelMQ100
      Applications
      ApplicationAnti-Peroxiredoxin 4 Antibody detects level of Peroxiredoxin 4 & has been published & validated for use in WB & IC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      ImmunogenFull-length human Peroxiredoxin 4 recombinant protein tagged with hexahistidine
      HostRabbit
      SpecificityPeroxiredoxin 4
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.
      Gene Symbol
      • PRDX4
      • Peroxiredoxin-4
      • AOE372
      • Prx-IV
      • AOE37-2
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13162 # Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
      SIZE: 271 amino acids; 30540 Da
      SUBUNIT: Homodimer or heterodimer with PRDX1; disulfide-linked, upon oxidation (By similarity).
      SUBCELLULAR LOCATION: Cytoplasm.
      SIMILARITY: SwissProt: Q13162 ## Belongs to the ahpC/TSA family.
      MISCELLANEOUS: The active site is the redox-active Cys-124 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-245-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin. & Irreversibly inactivated by overoxidation of Cys- 124 (to Cys-SO(3)H) upon oxidative stress.
      Molecular Weight21kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from Du145 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Peroxiredoxin 4 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Peroxiredoxin 4 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Peroxiredoxin 4 - 2537869 2537869
      Anti-Peroxiredoxin 4 - 27049 27049

      References

      Reference overviewPub Med ID
      Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alpha.
      Kang, Sang Won, et al.
      J. Biol. Chem., 279: 2535-43 (2004)  2004

      Show Abstract
      14597634 14597634
      Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells.
      Shen, Chuanlu and Nathan, Carl
      Mol. Med., 8: 95-102 (2002)  2002

      Show Abstract
      12080185 12080185

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress (EMD)

      Technical Info

      Title
      White Paper- Modern Methods in Oxidative Stress Research (EMD)

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies