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ABN1011 Anti-Peroxiredoxin-2 Antibody

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ABN1011
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, RWB, ICCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABN1011
      DescriptionAnti-Peroxiredoxin-2 Antibody
      Alternate Names
      • Peroxiredoxin-2
      • Thiol-specific antioxidant protein
      • TSA
      • Thioredoxin peroxidase 1
      • Thioredoxin-dependent peroxide reductase 1
      Background InformationThe protein called Peroxiredoxin-2, or in older literature Thiol-specific antioxidant protein, TSA, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Natural killer cell-enhancing factor B, PRP, or NKEF-B and encoded by the human gene PRDX2/NKEFB/TDPX1 plays a role in controlling the oxidation state of the cell by reducing peroxides via the Thioredoxin system. Peroxides are produced during normal metabolism and if not reduced, their built up can lead to oxidative stress and cell death. Interestingly Peroxirdoxin-2 can be inactivated itself by oxidative stress on Cys-51 thus its levels are tightly controlled. Peroxiredoxin-2 is particularly important in neurons where it acts as an anti-apoptotic factor but the protein is widely expressed and localizes to the cytoplasm in most cells. Because Peroxiredoxin-2 mediates H2O2 signaling it is considered an anti-aging and anti-cancer protein, but surprisingly recent research in yeast indicates that Peroxiredoxin-2 potentiates H202 levels and signaling by specifically inhibiting other Thioredoxin enzymes via their oxidation. Thus Peroxiredoxin-2 can both inhibit and promote peroxide metabolism depending upon the cellular microenvironment and cell systems being studied.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal serum without preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Peroxiredoxin-2 antibody is an antibody against Peroxiredoxin-2 for use in western blotting & ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blotting Analysis: A 1:1,000 dilution from a representative lot detected Peroxiredoxin-2 in 10 µg of human brain and rat hippocampus tissue lysate.

      Immunocytochemistry Analysis: A representative lot detected Peroxiredoxin-2 in COS cells (Prof. Mustapha Oulad, IGBMC, France.).
      Biological Information
      ImmunogenOvalbumin-conjugated linear peptide corresponding to the C-terminus of mouse Peroxiredoxin-2.
      EpitopeC-terminus
      HostRabbit
      Species Reactivity
      • Mouse
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Prdx2
      • Tdpx1
      • Tpx
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~22 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Peroxiredoxin-2 in 10 µg of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications