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ABC281 Anti-PRDX5 Antibody

ABC281
150 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC281
      DescriptionAnti-PRDX5 Antibody
      Alternate Names
      • Peroxiredoxin-5, mitochondrial
      • Alu corepressor 1
      • Antioxidant enzyme B166
      • AOEB166
      • Liver tissue 2D-page spot 71B
      • PLP
      • Peroxiredoxin V
      • Prx-V
      • Peroxisomal antioxidant enzyme
      • TPx type VI
      • Thioredoxin peroxidase PMP20
      • Thioredoxin reductase
      Background InformationPeroxiredoxin-5 (PRDX5) is a novel mammalian peroxiredoxin, belonging to the family of thiol-dependent peroxidases. It is structurally dissimilar from other peroxiredoxins in that it contains a conserved cysteine 47 residue at the N-terminus and a cysteine 151 residue at the C-terminus which form an intramolecular disulphide bridge and confers unique chemical characteristics to this enzyme. Peroxiredoxins protect cells from apoptosis induced by overexposure to endogenous or exogenous peroxides, such as peroxynitrites, hydrogen peroxide, and alkyl hydroperoxides. PRDX5 is widely expressed in various subcellular regions, including mitochondria, peroxisomes, nucleus, and cytosol.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse kidney tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide and 50% glycerol.
      Applications
      ApplicationThis PRDX5 antibody is validated for use in WB, IHC & IF for the detection of the PRDX5 protein.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PRDX5 in human kidney tissue.

      Immunofluorescence Analysis: A 1:25 dilution from a representative lot detected PRDX5 in HepG2 cells.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human PRDX5.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • PRDX5
      • ACR1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~17 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse kidney tissue lysate.

      Western Blotting Analysis: A 1:1,500 dilution of this antibody detected PRDX5 in 30 µg of mouse kidney tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size150 µL
      Transport Information
      Supplemental Information
      Specifications