ABC438 Anti-PKM2 Antibody

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IHC Rb Serum Polyclonal Antibody
      Catalogue NumberABC438
      DescriptionAnti-PKM2 Antibody
      Alternate Names
      • Pyruvate kinase PKM
      • Cytosolic thyroid hormone-binding protein
      • CTHBP
      • Opa-interacting protein 3
      • OIP-3
      • Pyruvate kinase 2/3
      • Pyruvate kinase muscle isozyme
      • Thyroid hormone-binding protein 1
      • THBP1
      • Tumor M2-PK
      • p58
      Background InformationPyruvate kinase isozymes M1/M2 (PKM2) is also called Cytosolic thyroid hormone-binding protein (CTHBP), Opa-interacting protein 3 (OIP-3), Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1 (THBP1) and p58. PKM2 is a glycolytic enzyme that assists in generating ATP. PKM2 also stimulates POU5F1-mediated transcriptional activation, and plays a role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. This control of glycolysis and is important for tumor cell proliferation and survival. PKM2 is specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, and cancer cells.
      Product Information
      PresentationRabbit polyclonal serum with 0.05% sodium azide.
      Quality LevelMQ100
      ApplicationAnti-PKM2 Antibody detects level of PKM2 & has been published & validated for use in WB and IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: A 1:1,000 dilution from a representative lot detected PKM2 in 10 µg of C2C12, HEK293, HeLa, HepG2, human placenta, HUVEC, Jurkat, L6, mouse brain, NIH/3T3, PC12, PC3, and RAW264.7 lysate.
      Western Blotting Analysis: A representative lot detected PKM2 in HEK293 cell lysate (Christofk, R. H., et al. (2008). Nature. 452:230-233).
      Immunohistochemistry Analysis: A representative lot detected PKM2 in HEK293 tissue (Christofk, R. H., et al. (2008). Nature. 452:230-233).
      Biological Information
      ImmunogenLinear peptide corresponding to human PKM2.
      SpecificityThis antibody is specific to PKM2.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PKM
      • OIP3
      • PK2
      • PK3
      • PKM2
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~ 58 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in A431 cell lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected PKM2 in 10 µg of A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information


      Anti-PKM2 Antibody SDS


      Safety Data Sheet (SDS) 

      Anti-PKM2 Antibody Certificates of Analysis

      TitleLot Number
      Anti-PKM2 - Q2428567Q2428567
      Anti-PKM2 - 32042133204213


      Reference overviewPub Med ID
      The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
      Christofk, Heather R, et al.
      Nature, 452: 230-3 (2008)  2008

      Show Abstract
      18337823 18337823

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      Life Science Research > Antibodies and Assays > Primary Antibodies