528215 Anti-PAI-1 Mouse mAb (MA-33B8)

Overview

Replacement Information

Key Specifications Table

Species ReactivityHostAntibody Type
H, Rb M Monoclonal Antibody

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
528215-100UG
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      Plastic ampoule 100 μg
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      Description
      OverviewRecognizes the ~50 kDa PAI-1 protein.
      Catalogue Number528215
      Brand Family Calbiochem®
      SynonymsAnti-Plasminogen Activator Inihibitor-1
      References
      ReferencesMontes, R., et al. 2000. Thromb. Haemost. 84, 65.
      Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
      Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta 1337, 257.
      Product Information
      FormLiquid
      FormulationIn 100 mM NaCl, 50 mM sodium phosphate buffer, pH 7.4.
      PreservativeNone
      Quality LevelMQ100
      Applications
      Application ReferencesNeutralization Studies Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
      Key Applications Immunoblotting (Western Blotting)
      Neutralization Studies
      Application NotesImmunoblotting (10 µg/ml)
      Neutralization Studies (see application references)
      Application CommentsRapidly inactivates PAI-1 (Plasminogen Activator Inhibitor-1) to the latent form. Like the native latent form, PAI-1 inactivated by antibody was protected from cleavage by elastase. Also shown to reduce renal fibrin deposits in a rabbit model of endotoxemia. Variables associated with assay conditions will dictate the proper working dilution.
      Biological Information
      Immunogenhuman tPA-PAI-1 complex
      ImmunogenHuman
      CloneMA-33B8
      HostMouse
      Purity≥ 90% by SDS-PAGE
      IsotypeIgG
      Species Reactivity
      • Human
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-PAI-1 Mouse mAb (MA-33B8) SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-PAI-1 Mouse mAb (MA-33B8) Certificates of Analysis

      TitleLot Number
      528215

      References

      Reference overview
      Montes, R., et al. 2000. Thromb. Haemost. 84, 65.
      Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
      Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta 1337, 257.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-March-2009 JSW
      SynonymsAnti-Plasminogen Activator Inihibitor-1
      ApplicationImmunoblotting (10 µg/ml)
      Neutralization Studies (see application references)
      DescriptionPurified mouse monoclonal antibody. Recognizes the ~50 kDa PAI-1 protein.
      HostMouse
      Immunogen speciesHuman
      Immunogenhuman tPA-PAI-1 complex
      CloneMA-33B8
      IsotypeIgG
      Specieshuman, rabbit
      FormLiquid
      FormulationIn 100 mM NaCl, 50 mM sodium phosphate buffer, pH 7.4.
      Concentration Label Please refer to vial label for lot-specific concentration
      Purity≥ 90% by SDS-PAGE
      PreservativeNone
      CommentsRapidly inactivates PAI-1 (Plasminogen Activator Inhibitor-1) to the latent form. Like the native latent form, PAI-1 inactivated by antibody was protected from cleavage by elastase. Also shown to reduce renal fibrin deposits in a rabbit model of endotoxemia. Variables associated with assay conditions will dictate the proper working dilution.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesMontes, R., et al. 2000. Thromb. Haemost. 84, 65.
      Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
      Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta 1337, 257.
      Application referencesNeutralization Studies Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.