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AB10522 Anti-Neuropilin-2 Antibody

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AB10522
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IHC, IP, IFRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10522
      ReplacesAB9160
      DescriptionAnti-Neuropilin-2 Antibody
      Alternate Names
      • Vascular endothelial cell growth factor 165 receptor 2
      • neuropilin 2
      • receptor for VEGF165 and semaphorins class 3
      • vascular endothelial growth factor-165 receptor 2
      Background InformationThere are two forms of Neuropilin: Neuropilin-1 and Neuropilin-2. These are non–tyrosine kinase receptors that bind to VEGF and semaphorins (SEMA3A, SEMA3B, and SEMA3F) and play an important role in the critical functioning of the nervous system. Neuropilin-2 is expressed in tumor cells, and mature and developing endothelial cells and vascular smooth muscle cells. This expression has been associated with tumor angiogenesis and progression.
      References
      Product Information
      FormatSerum
      Control
      • Mouse P1 brain tissue lysate
      PresentationUnpurified Rabbit Serum containing 0.05% Sodium Azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Neuropilin-2 using this Anti-Neuropilin-2 Antibody validated for use in WB, IH, IP & IF.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunoprecipitation
      • Immunofluorescence
      Biological Information
      ImmunogenHis-tagged partial recombinant rat Neuropilin-2 protein.
      EpitopeUnknown
      HostRabbit
      SpecificityThis antibody recognizes Neuropilin-2.
      IsotypeIgG
      Species Reactivity
      • Mouse
      Species Reactivity NoteProven to react with mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NRP2
      • NP2
      • NPN2
      • PRO2714
      • VEGF165R2
      • VEGF1265R2
      • 1110048P06Rik
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

      SUBUNIT STRUCTURE: Heterodimer with NRP1 Probable. Binds PLXNB1 By similarity.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICITY: Found in certain neuronal populations of the CNS and in other non-neuronal tissues including mesenchymal tissue lining in the ribs.

      DEVELOPMENTAL STAGE: The expression pattern is very dynamic and is developmentally regulated.

      SEQUENCE SIMILARITIES: Belongs to the neuropilin family.

      Contains 2 CUB domains.

      Contains 2 F5/8 type C domains.

      Contains 1 MAM domain.
      Molecular Weight 130 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse P1 brain tissue lysate.

      Western Blot Analysis: 1:1000 dilution of this antibody detected Neuropilin-2 on 10 µg of mouse P1 brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Neuropilin-2 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Neuropilin-2 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Neuropilin-2 - 2429680 2429680
      Anti-Neuropilin-2 - 2446917 2446917
      Anti-Neuropilin-2 - JBC1787346 JBC1787346
      Anti-Neuropilin-2 - NG1886559 NG1886559
      Anti-Neuropilin-2 - NRG1649488 NRG1649488
      Anti-Neuropilin-2 -2733803 2733803
      Anti-Neuropilin-2 Polyclonal Antibody 3109234

      References

      Reference overviewPub Med ID
      Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.
      Giger, R J, et al.
      Neuron, 21: 1079-92 (1998)  1998

      Show Abstract
      9856463 9856463

      Related Products & Applications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies