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06-984-25UG Anti-Mn-SOD

25 μg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, M, BIHC, IH(P), WBRbPurifiedPolyclonal Antibody
      Catalogue Number06-984-25UG
      Brand Family Upstate
      Trade Name
      • Upstate
      Alternate Names
      • Mn superoxide dismutase
      • indophenoloxidase B
      • manganese superoxide dismutase
      • manganese-containing superoxide dismutase
      • mangano-superoxide dismutase
      • superoxide dismutase 2, mitochondrial
      Background InformationSuperoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn SOD/SOD1), mitochondrial manganese SOD (Mn SOD/SOD2) and extracellular Cu, Zn SOD (EC SOD/SOD3). The manganese containing 80 kDa tetrameric enzyme SOD2 is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain.
      Product Information
      • L6 cell lysate, rat brain tissue extract.
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide.
      Quality LevelMQ100
      ApplicationAnti-Mn-SOD Antibody is an antibody against Mn-SOD for use in IH, IH(P) & WB.
      Key Applications
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry (Paraffin):
      10 μg/mL of a previous lot detected MnSOD in paraffin embedded rat brain tissue sections.
      Biological Information
      ImmunogenRecombinant human MnSOD (manganous superoxide dismutase).
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityRecognizes MnSOD, Mr 24 kDa.
      Species Reactivity
      • Human
      • Rat
      • Mouse
      • Bovine
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
      Gene Symbol
      • SOD2
      • Mn-SOD
      • MNSOD
      • MnSOD
      • IPO-B
      Non-Reactive Species
      • Canine
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04179 # Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
      COFACTOR: Binds 1 manganese ion per subunit.
      SIZE: 222 amino acids; 24722 Da
      SUBUNIT: Homotetramer.
      SUBCELLULAR LOCATION: Mitochondrion matrix.SIMILARITY:SwissProt: P04179 ## Belongs to the iron/manganese superoxide dismutase family.
      Molecular Weight~24 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by western blot on RIPA lysates of MCF-7, A431 or rat L6 RIPA cells.

      Western Blot Analysis:
      0.5-2 μg/mL of this antibody detected MnSOD in RIPA lysates of rat L6 RIPA cells. 1-4 μg/mL of a previous lot detected MnSOD in RIPA lysates of human MCF-7, A431 and rat L6 RIPA cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2 to 8ºC from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information